IFNL3/4 polymorphisms as a two‐edged sword: An association with COVID‐19 outcome
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28506
Abstract: Coronavirus Disease 2019 (COVID‐19) has been ranked among the most fatal infectious diseases worldwide, with host's immune response significantly affecting the prognosis. With an aim to timely predict the most likely outcome of SARS‐CoV‐2 infection,… read more here.
Keywords: ifnl4; ifnl3 polymorphisms; outcome; polymorphisms two ... See more keywords
IFNL4: Notable Variants and Associated Phenotypes.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144289
Abstract: Interferon lambda proteins activate the JAK-STAT signalling pathway, resulting in upregulation of genes with antiviral effects. The interferon lambda family was initially thought to be redundant to the interferon alpha family, which signals through the… read more here.
Keywords: associated phenotypes; ifnl4; ifnl4 notable; notable variants ... See more keywords
IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2066612
Abstract: ABSTRACT Individuals lacking interferon lambda 4 (IFNL4) protein due to a common null mutation (rs368234815) in the IFNL4 gene display higher resistance against several infections. The influence of IFNL4 on HIV-1 infection is still under… read more here.
Keywords: ifnl4; hiv; sex men; ifnl4 genotype ... See more keywords