Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048793
Abstract: Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling pathway, which also governs… read more here.
Keywords: response; cellular responses; viral infections; ifns ... See more keywords
Intronless and intron‐containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.10.007
Abstract: ABSTRACT Type I IFNs are considered to be the core IFN species in vertebrates because of their predominant antiviral effects. But, a puzzling question remains to be answered, as to how intronless type I IFN… read more here.
Keywords: ifn genes; ifns; type ifn; type ifns ... See more keywords
Lambda interferons in immunity and autoimmunity.
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DOI: 10.1016/j.jaut.2019.102319
Abstract: Type I IFNs are well known players in immunity and autoimmunity. They induce potent innate and adaptive immune responses essential for mediating host defenses against viral and bacterial infections but also driving inflammation during chronic… read more here.
Keywords: immunity autoimmunity; lambda interferons; ifns; type ifns ... See more keywords
Avian Interferons and Their Antiviral Effectors
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DOI: 10.3389/fimmu.2017.00049
Abstract: Interferon (IFN) responses, mediated by a myriad of IFN-stimulated genes (ISGs), are the most profound innate immune responses against viruses. Cumulatively, these IFN effectors establish a multilayered antiviral state to safeguard the host against invading… read more here.
Keywords: ifn; ifns; antiviral effectors; avian interferons ... See more keywords