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   Articles with "ift complex" as a keyword



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CEP19–RABL2–IFT-B axis controls BBSome-mediated ciliary GPCR export

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recommendations! Published in 2022 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e22-05-0161

Abstract: The intraflagellar transport (IFT) machinery mediates the import and export of ciliary proteins across the ciliary gate, as well as bidirectional protein trafficking within cilia. In addition to ciliary anterograde protein trafficking, the IFT-B complex… read more here.

Keywords: ift complex; ift25 ift27; ift; export ... See more keywords
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Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.07.05.498886

Abstract: Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the… read more here.

Keywords: intraflagellar transport; transport ift; ift complex; transport ... See more keywords
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Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis

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recommendations! Published in 2018 at "Biology Open"

DOI: 10.1242/bio.033241

Abstract: ABSTRACT In the intraflagellar transport (IFT) machinery, the IFT-B and IFT-A complexes mediate anterograde and retrograde ciliary protein trafficking, respectively. Among the 16 subunits of the IFT-B complex, several subunits are essential for ciliogenesis, whereas… read more here.

Keywords: ciliogenesis; ift70; ift complex; ift52 ift88 ... See more keywords
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Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis

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recommendations! Published in 2017 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1006627

Abstract: Intraflagellar transport (IFT) particles or trains are composed of IFT-A and IFT-B complexes. To assess the working mechanism of the IFT-A complex in IFT and ciliogenesis, we have analyzed ift43 mutants of Chlamydomnonas in conjunction… read more here.

Keywords: ciliogenesis; intraflagellar transport; ift complex; ift43 ... See more keywords
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WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium

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recommendations! Published in 2023 at "Life Science Alliance"

DOI: 10.26508/lsa.202201844

Abstract: Our research reveals that the deletion of WDR-31, RP-2, and ELMD-1 is leading to ciliary accumulation of IFT Complex B components and KIF17 kinesin. In conclusion, WDR31, ELMOD, and RP2 are working in regulating IFT… read more here.

Keywords: regulating ift; elmod rp2; ift complex; wdr31 displays ... See more keywords

TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13071191

Abstract: Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia. The dysfunction of IFT leads to ciliopathies of variable severity. Two of the IFT-B components are the paralogue proteins TTC30A… read more here.

Keywords: redundancy; ciliogenesis; ttc30a ttc30b; ift complex ... See more keywords