Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration
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DOI: 10.1002/eji.201646782
Abstract: The cross‐linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce… read more here.
Keywords: block iga; iga; skin; peptide mimetics ... See more keywords
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG‐ and IgA‐producing cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747264
Abstract: It is well established that dendritic cells and macrophages play a role in antigen presentation to B and T cells and in shaping B and T cell responses via cytokines they produce. We have previously… read more here.
Keywords: murine; production; iga; igg iga ... See more keywords
Specific microbiota enhances intestinal IgA levels by inducing TGF‐β in T follicular helper cells of Peyer's patches in mice
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DOI: 10.1002/eji.201948474
Abstract: In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF‐β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote… read more here.
Keywords: iga levels; intestinal iga; microbiota; iga ... See more keywords
Underutilization of diagnostic assays for celiac disease in Korea.
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DOI: 10.1002/jcla.23913
Abstract: BACKGROUND Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea.… read more here.
Keywords: iga; disease; celiac disease; disease korea ... See more keywords
Complement activation in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunopathology"
DOI: 10.1007/s00281-021-00882-9
Abstract: IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement… read more here.
Keywords: iga; complement activation; iga nephropathy; complement activity ... See more keywords
Anti-gliadin antibodies in breast milk from celiac mothers on a gluten-free diet
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DOI: 10.1007/s00394-017-1476-1
Abstract: PurposeTo analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND).Methods218 samples of mature milk… read more here.
Keywords: gluten free; gliadin antibodies; iga; total iga ... See more keywords
Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity
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DOI: 10.1007/s00425-019-03215-1
Abstract: An edible plant was tested as a host for the production of secretory monoclonal IgA against Shiga toxin 1 (Stx1). The lettuce-derived IgA completely protected Vero cells from Stx1. Secretory immunoglobulin A (SIgA) is thought… read more here.
Keywords: iga; lettuce derived; toxin; shiga toxin ... See more keywords
Severe Aspergillus Pneumonia and Pulmonary Artery Hypertension in a Child with Autosomal Recessive Chronic Granulomatous Disease and Selective IgA Deficiency
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DOI: 10.1007/s10875-017-0386-6
Abstract: To the editor Chronic granulomatous disease (CGD) is a phagocyte disorder characterized by a defect in the neutrophil respiratory burst that predisposes to recurrent infections with catalase-positive microorganisms [1, 2]. In addition, these patients have… read more here.
Keywords: selective iga; chronic granulomatous; iga; disease ... See more keywords
Immunoglobulin A vasculitis without purpura in an elderly female patient: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-021-01422-6
Abstract: Immunoglobulin A (IgA) vasculitis mainly affects the joints, skin, kidneys, and gastrointestinal tract; however, purpura is an essential diagnostic criterion. Here, we report an unusual case of IgA vasculitis without purpura in an elderly woman.… read more here.
Keywords: vasculitis; iga; without purpura; vasculitis without ... See more keywords
IgA deficiency and autoimmune comorbidities in Juvenile Idiopathic Arthritis.
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DOI: 10.1016/j.anpede.2022.03.004
Abstract: OBJECTIVES (1) To describe the prevalence of IgA deficiency (IgAD), uveitis, coeliac disease (CD) and thyroid disorders in a multicentric cohort of patients diagnosed with JIA and, (2) to evaluate whether patients with JIA and… read more here.
Keywords: autoimmune; iga deficiency; iga; autoimmune comorbidities ... See more keywords
Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris
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DOI: 10.1016/j.celrep.2018.07.093
Abstract: SUMMARY Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently… read more here.
Keywords: pemphigus vulgaris; disease pemphigus; iga; autoimmune disease ... See more keywords