Subcutaneous Allergen‐Specific Immunotherapy for Allergic Rhinitis: Divergent IgA Responses in Nasal Mucosa and Blood With Validation of B Cell Class‐Switching in Lymph Nodes and Blood
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DOI: 10.1002/clt2.70097
Abstract: ABSTRACT Background Subcutaneous immunotherapy (SCIT) has been a cornerstone treatment for allergic rhinitis (AR) for over 50 years, consistently demonstrating symptom reduction and modulation of immune responses. Despite this, the underlying mechanisms responsible for the… read more here.
Keywords: iga; nasal mucosa; lymph nodes; cell class ... See more keywords
Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration
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DOI: 10.1002/eji.201646782
Abstract: The cross‐linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce… read more here.
Keywords: block iga; iga; skin; peptide mimetics ... See more keywords
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG‐ and IgA‐producing cells
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DOI: 10.1002/eji.201747264
Abstract: It is well established that dendritic cells and macrophages play a role in antigen presentation to B and T cells and in shaping B and T cell responses via cytokines they produce. We have previously… read more here.
Keywords: murine; production; iga; igg iga ... See more keywords
Specific microbiota enhances intestinal IgA levels by inducing TGF‐β in T follicular helper cells of Peyer's patches in mice
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DOI: 10.1002/eji.201948474
Abstract: In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF‐β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote… read more here.
Keywords: iga levels; intestinal iga; microbiota; iga ... See more keywords
Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages
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DOI: 10.1002/eji.70068
Abstract: Severe COVID‐19 is an immunological disorder characterized by a hyper‐inflammatory reaction of the immune system. SARS‐CoV‐2 anti‐spike antibodies of the IgG isotype are known to strongly contribute to this hyperinflammation by overactivation of alveolar macrophages.… read more here.
Keywords: sars cov; iga; macrophages anti; iga2 ... See more keywords
Underutilization of diagnostic assays for celiac disease in Korea.
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DOI: 10.1002/jcla.23913
Abstract: BACKGROUND Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea.… read more here.
Keywords: iga; disease; celiac disease; disease korea ... See more keywords
Identifying Core Issues for Basin Management: The Issue Generating Assessment (IGA) Methodology
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DOI: 10.1007/s00267-024-01981-7
Abstract: Effective stakeholder engagement is essential for basin management, requiring structured approaches to foster collaboration and consensus. This paper applies the Issue Generating Assessment (IGA) method, which identifies core issues for stakeholder discussion, to basin management.… read more here.
Keywords: methodology; iga; core issues; basin management ... See more keywords
Complement activation in IgA nephropathy.
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DOI: 10.1007/s00281-021-00882-9
Abstract: IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement… read more here.
Keywords: iga; complement activation; iga nephropathy; complement activity ... See more keywords
Anti-gliadin antibodies in breast milk from celiac mothers on a gluten-free diet
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DOI: 10.1007/s00394-017-1476-1
Abstract: PurposeTo analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND).Methods218 samples of mature milk… read more here.
Keywords: gluten free; gliadin antibodies; iga; total iga ... See more keywords
Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity
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DOI: 10.1007/s00425-019-03215-1
Abstract: An edible plant was tested as a host for the production of secretory monoclonal IgA against Shiga toxin 1 (Stx1). The lettuce-derived IgA completely protected Vero cells from Stx1. Secretory immunoglobulin A (SIgA) is thought… read more here.
Keywords: iga; lettuce derived; toxin; shiga toxin ... See more keywords
Proportions of IgA antibodies targeting glycosylated epitopes of secreted Escherichia coli mucinase YghJ in initial plasmablast response differ from salivary and intestinally secreted IgA
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DOI: 10.1007/s00430-024-00812-0
Abstract: Mucosal infections normally cause an immune response including activation of antigen-specific B cells in regional mucosa-associated lymphoid tissue. After recirculation of plasmablasts, and maturation at mucosal surfaces or bone marrow, plasma cells produce secretory or… read more here.
Keywords: escherichia coli; iga; targeting glycosylated; glycosylated epitopes ... See more keywords