Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy
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DOI: 10.1126/sciadv.add6734
Abstract: Immunoglobulin A (IgA) nephropathy (IgAN) is the most common type of primary glomerulonephritis, often progressing to renal failure. IgAN is triggered by IgA deposition in the glomerular mesangium by an undefined mechanism. Here, we show… read more here.
Keywords: iga autoantibodies; iga nephropathy; mesangial cells; iga ... See more keywords
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202201-0011oc
Abstract: Rationale Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives To assess whether IgA autoantibodies target lung-specific… read more here.
Keywords: iga autoantibodies; severe covid; patients severe; surfactant proteins ... See more keywords