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   Articles with "iga1" as a keyword



Oxidative stress and macrophage infiltration in IgA nephropathy

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recommendations! Published in 2021 at "Journal of Nephrology"

DOI: 10.1007/s40620-021-01196-7

Abstract: The aim of this study was to evaluate the interactions among serum levels of galactose-deficient IgA1 (Gd-IgA1), oxidative stress and macrophage infiltration and their clinical correlates in patients with IgA Nephropathy (IgAN). A total of… read more here.

Keywords: stress macrophage; iga nephropathy; iga1; macrophage infiltration ... See more keywords

Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy

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recommendations! Published in 2020 at "Kidney International Reports"

DOI: 10.1016/j.ekir.2019.10.012

Abstract: Introduction Galactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN). However, their roles in the development of secondary IgAN are still unknown.… read more here.

Keywords: plasma iga1; iga nephropathy; igg; iga1 ... See more keywords

Influence of media composition on recombinant monoclonal IgA1 glycosylation analysed by lectin-based protein microarray and MALDI-MS

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recommendations! Published in 2020 at "Journal of Biotechnology"

DOI: 10.1016/j.jbiotec.2020.03.009

Abstract: Abstract Glycosylation of therapeutic glycoproteins significantly affects their physico-chemical properties, bioactivity and immunogenicity. The determination of glycan composition is highly important regarding their development and production. Therefore, there is a demand for analytical techniques enabling… read more here.

Keywords: protein microarray; based protein; lectin based; iga1 ... See more keywords

Are we ready for targeted therapy for IgA nephropathy?

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recommendations! Published in 2017 at "The Lancet"

DOI: 10.1016/s0140-6736(17)30820-6

Abstract: Almost 50 years have passed since the initial description of IgA nephropathy by Berger and Hinglais. IgA nephropathy is the most common chronic glomerulonephritis in the world. A renal biopsy is required for diagnosis but… read more here.

Keywords: iga nephropathy; ready targeted; iga; treatment ... See more keywords

Asymmetric N-Glycosylation in the Tailpiece of Recombinant IgA1

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c13156

Abstract: Here, we employed a variety of mass spectrometry (MS)-based approaches, both (glyco)peptide-centric and protein-centric, to resolve the complex glycoproteoform landscape of recombinant IgA1 produced in HEK293 cells. These key immunoglobulins harbor several N- and O-glycosylation… read more here.

Keywords: tailpiece; recombinant iga1; glycosylation site; glycosylation sites ... See more keywords

Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60819-w

Abstract: The retention of galactose-deficient IgA1 (Gd-IgA1) in the mesangium is central to IgA nephropathy (IgAN), but its intracellular fate remains unclear. Here, we show that transferrin receptor 1 (TfR1) mediates Gd-IgA1 uptake into mesangial cell… read more here.

Keywords: transferrin receptor; iga nephropathy; iga1; deficient iga1 ... See more keywords

Emerging role of monoclonal antibodies in the treatment of IgA nephropathy

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recommendations! Published in 2023 at "Expert Opinion on Biological Therapy"

DOI: 10.1080/14712598.2023.2213800

Abstract: ABSTRACT Introduction IgA nephropathy is the most common primary glomerulonephritis worldwide. Immune complexes, composed of galactose-deficient IgA1 and Gd-IgA1 autoantibodies, are deposited in the mesangial area of the glomeruli where they induce complement-mediated inflammation. This… read more here.

Keywords: treatment iga; iga nephropathy; monoclonal antibodies; iga1 ... See more keywords

MO039THE 24-WEEK INTERIM ANALYSIS RESULTS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE II STUDY OF ATACICEPT IN PATIENTS WITH IGA NEPHROPATHY AND PERSISTENT PROTEINURIA

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa140.mo039

Abstract: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Despite being described over 50 years ago, there remains no approved therapy for this common global cause of kidney failure. The central pathogenic… read more here.

Keywords: week; week interim; iga1; interim analysis ... See more keywords

P0301FIT FOR PURPOSE VALIDATION OF A CLINICAL ASSAY FOR THE DETECTION OF SERUM LEVELS OF GALACTOSE-DEFICIENT IMMUNOGLOBULIN A1 (GD-IGA1) IN PATIENTS WITH IGA NEPHROPATHY (IGAN)

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa142.p0301

Abstract: Analysis of serum or plasma from patients with IgA nephropathy (IgAN) has confirmed the presence of elevated levels of circulating immune complexes containing Gd-IgA1 (Czerkinsky 1986). New sensitive and reasonably specific noninvasive tests are emerging… read more here.

Keywords: nephropathy igan; iga nephropathy; validation; patients iga ... See more keywords

Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries

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recommendations! Published in 2022 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfac204

Abstract: ABSTRACT Background Galactose-deficient immunoglobulin A1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathological role of Gd-IgA1-containing immune complexes (ICs) and the mechanism of deposition in the mesangial region… read more here.

Keywords: iga1 containing; glomerular endothelial; deposition; endothelial cell ... See more keywords

#1323 Mesangioproliferative activity of IgA1-IgG immune complexes in IgA nephropathy requires complement C3 and can be inhibited by a broad-spectrum kinase inhibitor

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.0250

Abstract: IgA nephropathy (IgAN) is an immune-complex (IC)-mediated kidney disease wherein ICs form in the circulation by aberrantly O-glycosylated IgA1 (galactose-deficient IgA1; Gd-IgA1) and IgG autoantibodies. Additional serum components, such as complement proteins, can also be… read more here.

Keywords: igg; mesangial cells; iga igg; iga1 ... See more keywords