Oxidative stress and macrophage infiltration in IgA nephropathy
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DOI: 10.1007/s40620-021-01196-7
Abstract: The aim of this study was to evaluate the interactions among serum levels of galactose-deficient IgA1 (Gd-IgA1), oxidative stress and macrophage infiltration and their clinical correlates in patients with IgA Nephropathy (IgAN). A total of… read more here.
Keywords: stress macrophage; iga nephropathy; iga1; macrophage infiltration ... See more keywords
Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy
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DOI: 10.1016/j.ekir.2019.10.012
Abstract: Introduction Galactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN). However, their roles in the development of secondary IgAN are still unknown.… read more here.
Keywords: plasma iga1; iga nephropathy; igg; iga1 ... See more keywords
Influence of media composition on recombinant monoclonal IgA1 glycosylation analysed by lectin-based protein microarray and MALDI-MS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biotechnology"
DOI: 10.1016/j.jbiotec.2020.03.009
Abstract: Abstract Glycosylation of therapeutic glycoproteins significantly affects their physico-chemical properties, bioactivity and immunogenicity. The determination of glycan composition is highly important regarding their development and production. Therefore, there is a demand for analytical techniques enabling… read more here.
Keywords: protein microarray; based protein; lectin based; iga1 ... See more keywords
Are we ready for targeted therapy for IgA nephropathy?
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DOI: 10.1016/s0140-6736(17)30820-6
Abstract: Almost 50 years have passed since the initial description of IgA nephropathy by Berger and Hinglais. IgA nephropathy is the most common chronic glomerulonephritis in the world. A renal biopsy is required for diagnosis but… read more here.
Keywords: iga nephropathy; ready targeted; iga; treatment ... See more keywords
Emerging role of monoclonal antibodies in the treatment of IgA nephropathy
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DOI: 10.1080/14712598.2023.2213800
Abstract: ABSTRACT Introduction IgA nephropathy is the most common primary glomerulonephritis worldwide. Immune complexes, composed of galactose-deficient IgA1 and Gd-IgA1 autoantibodies, are deposited in the mesangial area of the glomeruli where they induce complement-mediated inflammation. This… read more here.
Keywords: treatment iga; iga nephropathy; monoclonal antibodies; iga1 ... See more keywords
MO039THE 24-WEEK INTERIM ANALYSIS RESULTS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE II STUDY OF ATACICEPT IN PATIENTS WITH IGA NEPHROPATHY AND PERSISTENT PROTEINURIA
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa140.mo039
Abstract: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Despite being described over 50 years ago, there remains no approved therapy for this common global cause of kidney failure. The central pathogenic… read more here.
Keywords: week; week interim; iga1; interim analysis ... See more keywords
P0301FIT FOR PURPOSE VALIDATION OF A CLINICAL ASSAY FOR THE DETECTION OF SERUM LEVELS OF GALACTOSE-DEFICIENT IMMUNOGLOBULIN A1 (GD-IGA1) IN PATIENTS WITH IGA NEPHROPATHY (IGAN)
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0301
Abstract: Analysis of serum or plasma from patients with IgA nephropathy (IgAN) has confirmed the presence of elevated levels of circulating immune complexes containing Gd-IgA1 (Czerkinsky 1986). New sensitive and reasonably specific noninvasive tests are emerging… read more here.
Keywords: nephropathy igan; iga nephropathy; validation; patients iga ... See more keywords
Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries
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DOI: 10.1093/ndt/gfac204
Abstract: ABSTRACT Background Galactose-deficient immunoglobulin A1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathological role of Gd-IgA1-containing immune complexes (ICs) and the mechanism of deposition in the mesangial region… read more here.
Keywords: iga1 containing; glomerular endothelial; deposition; endothelial cell ... See more keywords
Glomerular galactose‐deficient IgA1 detected in donor‐derived and recurrent IgA nephropathy
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DOI: 10.1111/tri.14009
Abstract: Galactose deficient IgA1 (Gd-IgA1) plays an important role in the pathogenesis of IgA nephropathy (IgAN)1 . Immunofluorescence (IF) staining of KM55, a Gd-IgA1 specific monoclonal antibody, becomes an easy and reliable tool to detect Gd-IgA1… read more here.
Keywords: iga nephropathy; glomerular galactose; iga1; galactose deficient ... See more keywords
ELL2 Is Downregulated and Associated with Galactose-Deficient IgA1 in IgA Nephropathy
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DOI: 10.1155/2019/2407067
Abstract: Background Galactose-deficient IgA1 (Gd-IgA1) is an important causal factor in IgA nephropathy; however, the underlying mechanism for the production of Gd-IgA1 is unknown. The elongation factor for RNA polymerase II (ELL2), which encoded a key… read more here.
Keywords: iga nephropathy; iga1; galactose deficient; expression ... See more keywords
Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy
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DOI: 10.1186/s12882-017-0722-3
Abstract: BackgroundAccumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have been identified as major components in cIgA1. Before, Gd-IgA1 was reported… read more here.
Keywords: specific igg; igg; iga1; mesangial cells ... See more keywords