Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy
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DOI: 10.1159/000499110
Abstract: Background: Aberrant O-glycosylation IgA1 production is a major factor in the pathogenesis of IgA nephropathy, but the underlying mechanism is still unclear. IgA1 glycosylation modification is in Golgi, and downregulation of the Golgi peripheral membrane… read more here.
Keywords: iga nephropathy; gm130; iga1 glycosylation; glycosylation ... See more keywords
IgA1 Glycosylation Is Heritable in Healthy Twins.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016020184
Abstract: IgA nephropathy (IgAN) is the most common form of primary GN and an important cause of kidney failure. Characteristically, patients with IgAN have increased serum levels of undergalactosylated IgA1 (gd-IgA1). To assess the degree to… read more here.
Keywords: iga1 glycosylation; serum iga1; iga1; serum ... See more keywords