MicroRNAs in IgA nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "Renal Failure"
DOI: 10.1080/0886022x.2021.1977320
Abstract: Abstract IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. It is considered that the pathogenesis of IgAN involves the ‘multiple hit theory’ and the immune-inflammatory mechanism; however, these theories have certain limitations. The… read more here.
Keywords: iga nephropathy; igan; micrornas iga;
Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16520
Abstract: Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance‐based metabolomic profiling and identified 26 metabolites in urine samples. We collected… read more here.
Keywords: metabolomic profiling; igan; biomarker; urinary glycine ... See more keywords
Clinical course of Immunoglobulin A nephropathy with Crescents in a multi-ethnic Southeast Asian cohort.
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DOI: 10.1111/nep.13723
Abstract: INTRODUCTION Clinical presentation and course of Immunoglobulin A nephropathy vary by ethnicity and geography and significance of extracapillary proliferation or crescents (IgAN-C) in Southeast Asia is not well described. We aimed to describe the clinical… read more here.
Keywords: course immunoglobulin; immunoglobulin nephropathy; igan; clinical course ... See more keywords
Protocol and rationale for the first South Asian 5-year prospective longitudinal observational cohort study and biomarker evaluation investigating the clinical course and risk profile of IgA nephropathy: GRACE IgANI cohort
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DOI: 10.12688/wellcomeopenres.14644.1
Abstract: Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney disease. Unlike the slowly progressive course seen among Caucasian and East Asian subjects (actuarial survival 80-85% over 10… read more here.
Keywords: risk; igan; iga nephropathy; year ... See more keywords
Complement factor H variants are associated with microangiopathy lesions in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4109826
Abstract: BACKGROUND Thrombotic microangiopathy (TMA) occurs in immunoglobulin A nephropathy (IgAN), and the pathogenesis is not known behind the endothelium injury. The genetic studies have indicated that complement factor H (CFH) and complement factor H-related protein… read more here.
Keywords: factor; complement factor; cfh; study ... See more keywords
Development and validation of diagnostic models for immunoglobulin A nephropathy based on gut microbes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1059692
Abstract: Background Immunoglobulin A nephropathy (IgAN) is a highly prevalent glomerular disease. The diagnosis potential of the gut microbiome in IgAN has not been fully evaluated. Gut microbiota, serum metabolites, and clinical phenotype help to further… read more here.
Keywords: gut; gut microbiota; diagnosis; immunoglobulin nephropathy ... See more keywords
Causal effects between gut microbiota and IgA nephropathy: a bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1171517
Abstract: Background Therapeutic approaches that target the gut microbiota (GM) may be helpful in the potential prevention and treatment of IgA nephropathy (IgAN). Meanwhile, relevant studies demonstrated a correlation between GM and IgAN, however, these confounding… read more here.
Keywords: iga nephropathy; gut microbiota; analysis; causal ... See more keywords
A Mendelian randomization study to assess the genetic liability of type 1 diabetes mellitus for IgA nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1000627
Abstract: Background The prevalence of immunoglobulin A nephropathy (IgAN) seems to be higher in patients with type 1 diabetes mellitus (T1DM) than that in the general population. However, whether there exists a causal relationship between T1DM… read more here.
Keywords: mendelian randomization; type diabetes; diabetes mellitus; t1dm ... See more keywords