ZINC-592 Ameliorates IgE-Mediated Chronic Inflammatory Responses of Viral Infections via Keap1/Nrf2 Signaling.
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DOI: 10.1002/bab.70037
Abstract: Chronic inflammation triggered by viral infections poses significant challenges to human health. This study aims to evaluate the potential of ZINC-592, a novel Keap1 inhibitor, in mitigating chronic inflammation associated with viral infections mediated by… read more here.
Keywords: ige mediated; zinc 592; keap1; zinc ... See more keywords
IgE‐mediated regulation of IL‐10 and type I IFN enhances rhinovirus‐induced Th2 differentiation by primary human monocytes
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948396
Abstract: Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell… read more here.
Keywords: ige mediated; th2 differentiation; induced th2; rhinovirus ... See more keywords
SHIP‐1 Differentially Regulates IgE‐Induced IL‐10 and Antiviral Responses in Human Monocytes
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DOI: 10.1002/eji.202451065
Abstract: IgE‐mediated stimulation of monocytes regulates multiple cellular functions including cellular maturation, cytokine release, antiviral responses, and T‐cell differentiation. Expression of the high‐affinity IgE receptor, FcεRI, is closely linked to serum IgE levels and atopic disease.… read more here.
Keywords: human monocytes; ige mediated; antiviral responses; ship ... See more keywords
KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE‐mediated Activation
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202451348
Abstract: Incidents of IgE-mediated, mast cell (MC)-driven allergic diseases are constantly rising and there is an urgent need for the development of novel pharmacological MC stabilizers. Allergen/antigen (Ag)-triggered activation of MCs via crosslinking of the high-affinity… read more here.
Keywords: mast cell; lyn fyn; ige mediated; activation ... See more keywords
The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE‐mediated mast cell activation
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DOI: 10.1002/jlb.3ab0320-547rr
Abstract: Mast cell activation through the high‐affinity IgE receptor (FcεRI) plays a central role in allergic reactions. FcεRI‐mediated activation triggers multiple signaling pathways leading to degranulation and synthesis of different inflammatory mediators. IgE‐mediated mast cell activation… read more here.
Keywords: mast cell; cell activation; cell; ige mediated ... See more keywords
Safety and effectiveness of milk and egg ladders in children with IgE-mediated food allergy-A case series.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1002/jpn3.70088
Abstract: OBJECTIVES Introducing baked cow's milk and egg proteins to children with severe immunoglobulin E (IgE)-mediated food allergies is controversial. This case series aimed to evaluate the safety and efficiency of the 5-step milk ladder (5-ML)… read more here.
Keywords: food; ige mediated; children ige; case ... See more keywords
Neonates undergoing gastrointestinal surgery have a higher incidence of non-IgE-mediated gastrointestinal food allergies
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DOI: 10.1007/s00383-018-4325-2
Abstract: PurposeWe aimed at investigating the incidence and risk factors of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) in neonates and infants.MethodsA total of 126 infants who underwent neonatal gastrointestinal surgeries were grouped into those with (n = 13) and… read more here.
Keywords: ige mediated; non ige; surgery; food allergies ... See more keywords
In vitro anti-inflammatory effects of curcumin on mast cell-mediated allergic responses via inhibiting FcεRI protein expression and protein kinase C delta translocation
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DOI: 10.1007/s10616-019-00359-6
Abstract: Allergy is a hypersensitivity reaction when exposed to certain environmental substances. It shows high relation between immunoglobulin E (IgE) binding to a specific receptor (FcεRI), pro-inflammatory cytokines, and mediators with allergic inflammation responses. Curcumin is… read more here.
Keywords: anti inflammatory; allergic responses; ige mediated; mediated allergic ... See more keywords
Is food protein induced enterocolitis syndrome only a non IgE-mediated food allergy?
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DOI: 10.1016/j.aller.2017.10.004
Abstract: Food protein induced enterocolitis syndrome (FPIES) is classified as non-IgE-mediated or cell-mediated food allergy, although there is an atypical phenotype so defined for the presence of specific IgEs. All diagnostic criteria for FPIES include the… read more here.
Keywords: ige mediated; protein induced; enterocolitis syndrome; induced enterocolitis ... See more keywords
WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114763
Abstract: Mast cells (MCs) play an important role as effector cells that cause allergic responses in allergic diseases. For these reasons, MC is considered an attractive therapeutic target for allergic disease treatment. In this study, we… read more here.
Keywords: ige mediated; allergic responses; lyn fyn; mediated allergic ... See more keywords
Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells
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DOI: 10.1038/s41598-019-52317-z
Abstract: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid mainly found in fish oil. Although several studies have suggested that it can alleviate allergy symptoms, its mechanism of action remains to be elucidated. In the… read more here.
Keywords: ige mediated; degranulation; cell degranulation; docosahexaenoyl ethanolamide ... See more keywords