MiR‐302b‐5p enhances the neuroprotective effect of IGF‐1 in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson's disease by regulating inducible nitric‐oxide synthase
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3534
Abstract: Parkinson's disease (PD) is a neurodegenerative disease which results in damage in neuronal cells. Insulin‐like growth factor (IGF)‐1 was previously reported to play a role of neuroprotection in some diseases. Nitric oxide (NO) can also… read more here.
Keywords: cell; disease; effect; igf ... See more keywords
Effect of intra‐BLA overexpression of IGF‐1 on the expression of a contextual fear memory trace
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23465
Abstract: Growth factors, such as insulin‐like growth factor 1 (IGF‐1), among others are known for their critical involvement in learning and memory processes. IGF‐1 regulates cognitive functions, synapse density, neurotransmission, and adult neurogenesis and induces structural… read more here.
Keywords: overexpression; bla; trace; fear ... See more keywords
Single nucleotide polymorphisms in the IGF‐IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE‐3 trial
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30715
Abstract: The Insulin‐like growth factor (IGF)/IGF‐receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the… read more here.
Keywords: patients enrolled; fire trial; mcrc; igf ... See more keywords
The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF‐1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3192
Abstract: The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin‐based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regulatory guanine… read more here.
Keywords: bone growth; bone; igf; myo9b ... See more keywords
Novel insights into the effect of deer IGF‐1 on chondrocyte viability and IL‐1β‐induced inflammation response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23227
Abstract: Clinical treatment of Osteoarthritis (OA) remains a challenge due to the poor self‐regeneration ability of cartilage. Deer antler is the only cartilage tissue that can completely regenerate each year. Insulin‐like growth factor 1 (IGF‐1) is… read more here.
Keywords: deer; chondrocyte; inflammation response; igf ... See more keywords
H19 regulates the proliferation of bovine male germline stem cells via IGF‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26920
Abstract: Self‐renewal and differentiation of male germline stem cells (mGSCs) provide the basic function for continual spermatogenesis. Studies of in vitro culture of germline stem cells are important and meaningful for basic biological research and practical… read more here.
Keywords: igf signaling; germline stem; signaling pathway; igf ... See more keywords
Protein kinase B/AKT mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28353
Abstract: Insulin‐like growth factor 1 (IGF‐1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone… read more here.
Keywords: hdac5 phosphorylation; nuclear export; igf; activation ... See more keywords
Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Osteoporosis International"
DOI: 10.1007/s00198-018-4638-y
Abstract: SummaryBone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes. This study showed for the first time that combined evaluation by serum insulin-like growth factor-I and BMD is useful to… read more here.
Keywords: serum insulin; bmd; insulin like; type diabetes ... See more keywords
An antibody-free LC-MS/MS method for the quantification of intact insulin-like growth factors 1 and 2 in human plasma
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03185-y
Abstract: Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) are important biomarkers in research and diagnosis of growth disorders. Quantitative analysis is performed using various ligand-binding assays or enzymatic digestion LC-MS/MS methods, whose widespread adoption… read more here.
Keywords: igf igf; method; insulin like; igf ... See more keywords
Effects of insulin-like growth factor-1 on endoplasmic reticulum stress and autophagy in rat gastric smooth muscle cells cultured at different glucose concentrations in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3388-7
Abstract: The purpose of the study was to observe changes in endoplasmic reticulum stress (ERS)- and autophagy-related proteins in gastric smooth muscle tissues of diabetic rats with gastroparesis, investigate the effect of insulin-like growth factor 1… read more here.
Keywords: normal glucose; group; gastric smooth; high glucose ... See more keywords
Insulin growth factor-1 pathway in cervical carcinoma cancer stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03807-6
Abstract: Cancer stem cells (CSC) drive tumour progression and are implicated in relapse and resistance to conventional cancer therapies. Identification of differentially expressed genes by gene expression (GEP) profiling may help identify the differentially activated signalling… read more here.
Keywords: cancer stem; inhibition; igf; cancer ... See more keywords