Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2022.2055376
Abstract: ABSTRACT Brain aging is a complex biological process often associated with a decline in cognitive functions and motility. Astaxanthin (AST) is a strong antioxidant capable of crossing the blood–brain barrier. The effect of AST on… read more here.
Keywords: brain aging; samp10 mice; brain; mechanism ... See more keywords
Progerin modulates the IGF-1R/Akt signaling involved in aging
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo0322
Abstract: Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like… read more here.
Keywords: signaling involved; modulates igf; akt signaling; progerin modulates ... See more keywords
Amelioration of Nicotine-Induced Osteoarthritis by Platelet-Derived Biomaterials Through Modulating IGF-1/AKT/IRS-1 Signaling Axis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Transplantation"
DOI: 10.1177/0963689720947348
Abstract: Besides inhalation, a few studies have indicated that the uptake of nicotine through air or clothing may be a significant pathway of its exposure among passive smokers. Nicotine is well known to exert various physiological… read more here.
Keywords: nicotine; akt irs; nicotine induced; modulating igf ... See more keywords
Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147853
Abstract: Cytochrome P450 enzymes (CYP450s) exert mighty catalytic actions in cellular metabolism and detoxication, which play pivotal roles in cell fate determination. Preliminary data shows differential expression levels of CYP27C1, one of the “orphan P450s” in… read more here.
Keywords: lung cancer; akt p53; anticancer agents; igf akt ... See more keywords