The effect of dietary pioglitazone supplementation on milk yield, insulin sensitivity and GH–IGF‐I axis in Holstein dairy cows during the transition period
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.1018
Abstract: Abstract Background High‐yielding dairy cows develop insulin resistance during late gestation associated with disruption of the growth hormone (GH)–insulin‐like growth factor (IGF)‐I axis and cause metabolic and reproductive disorders. Objective This study aimed to determine… read more here.
Keywords: supplementation; dairy cows; igf axis; insulin sensitivity ... See more keywords
Impact of CFTR-modulating drugs on GH-IGF-1 axis impairment in adult patients with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-019-01051-4
Abstract: IntroductionA new class of drugs in the treatment of cystic fibrosis (CF) includes two agents: lumacaftor, which corrects CFTR channel protein, and ivacaftor, which increases CFTR channel activity. In our previous study we recruited 50… read more here.
Keywords: cystic fibrosis; igf axis; cftr modulating; impact cftr ... See more keywords
Recombinant bovine growth hormone (rBGH) enhances somatic growth by regulating the GH-IGF axis in fingerlings of gilthead sea bream (Sparus aurata).
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.06.019
Abstract: The growth hormone (GH)/insulin-like growth factors (IGFs) endocrine axis is the main growth-regulator system in vertebrates. Some authors have demonstrated the positive effects on growth of a sustained-release formulation of a recombinant bovine GH (rBGH)… read more here.
Keywords: igf axis; rbgh; recombinant bovine; growth hormone ... See more keywords
Growth hormone/IGF‐1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon β‐1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neurology"
DOI: 10.1111/ene.13207
Abstract: Growth hormone (GH)/insulin‐like growth factor 1 (IGF‐1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN‐β) efficacy could be mediated also by an increase of IGF‐1 levels. A 2‐year… read more here.
Keywords: igf axis; clinically isolated; growth hormone; igf ... See more keywords
Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Endocrinology"
DOI: 10.1155/2019/7570146
Abstract: Background and Aims Hepatocellular carcinoma (HCC) is the common tumor of the liver. Unfortunately, most HCC seem to be resistant to conventional chemotherapy and radiotherapy. The poor efficacy of antitumor agents is also due, at… read more here.
Keywords: metf; igf axis; hcc; klf6 p21 ... See more keywords
Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215825
Abstract: Although mother-to-child transmission of HIV has dramatically declined, the number of in utero HIV-exposed, uninfected infants is on the increase. HIV-exposed infants are at an increased risk of mortality, morbidity and slower early growth than… read more here.
Keywords: growth; igf axis; hiv; axis angiogenic ... See more keywords
Different Roles of the Insulin-like Growth Factor (IGF) Axis in Non-small Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220608122934
Abstract: Non-small cell lung cancer (NSCLC) remains one of the deadliest malignant diseases, with high incidence and mortality worldwide. The insulin-like growth factor (IGF) axis, consisting of IGF-1, IGF-2, related receptors (IGF-1R, -2R), and high-affinity binding… read more here.
Keywords: non small; growth; small cell; cancer ... See more keywords
Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.641449
Abstract: Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the development of different types of solid tumors,… read more here.
Keywords: igf axis; breast cancer; role igf; igf ... See more keywords
Insulin-Like Growth Factor Axis Biomarkers and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00444
Abstract: The insulin-like growth factor (IGF) axis has been implicated in glucose homeostasis. It is plausible to hypothesize that the IGF axis is involved in the development of gestational diabetes mellitus (GDM). In a systematic review… read more here.
Keywords: gdm; axis biomarkers; igf axis; gestation ... See more keywords
Mini Review: Effect of GLP-1 Receptor Agonists and SGLT-2 Inhibitors on the Growth Hormone/IGF Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.846903
Abstract: Accumulating evidence supports the early use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium glucose transporter-2 inhibitors (SGLT-2is) for the treatment of type 2 diabetes. Indeed, these compounds exert numerous pleiotropic actions that favorably affect… read more here.
Keywords: receptor agonists; growth hormone; mini review; igf ... See more keywords
Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01418
Abstract: Myostatin, a negative regulator of muscle growth, is considered a potential therapeutic agent for individuals suffering from various muscle wasting and strength declining diseases because inhibiting Mstn signaling leads to muscular hypertrophy. In this study… read more here.
Keywords: strength; muscle strength; myostatin; igf axis ... See more keywords