An antibody-free LC-MS/MS method for the quantification of intact insulin-like growth factors 1 and 2 in human plasma
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03185-y
Abstract: Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) are important biomarkers in research and diagnosis of growth disorders. Quantitative analysis is performed using various ligand-binding assays or enzymatic digestion LC-MS/MS methods, whose widespread adoption… read more here.
Keywords: igf igf; method; insulin like; igf ... See more keywords
Serum minerals (Ca, P, Co, Mn, Ni, Cd) and growth hormone (IGF-1 and IGF-2) levels in postmenopausal Saudi women with osteoporosis
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DOI: 10.1097/md.0000000000020840
Abstract: Abstract Osteoporosis is reported to be common among Saudi women. Several minerals appear to be important determinants of insulin-like growth factor (IGF), the bioactivity of which regulates bone and mineral metabolism. Here we proposed that… read more here.
Keywords: igf igf; saudi women; postmenopausal saudi; women osteoporosis ... See more keywords
Effects of gastric sleeve surgery on the serum levels of GH, IGF-1 and IGF-binding protein 2 in healthy obese patients
Sign Up to like & getrecommendations! Published in 2020 at "BMC Gastroenterology"
DOI: 10.1186/s12876-020-01309-9
Abstract: Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1… read more here.
Keywords: igfbp; gastric sleeve; surgery; igf igf ... See more keywords
Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
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DOI: 10.1186/s12902-018-0271-1
Abstract: BackgroundInsulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP).MethodsWe assessed… read more here.
Keywords: igf 3580; igf; igf igf; cpp group ... See more keywords
IGF-1 and IGF-1 SDS - fit for purpose?
Sign Up to like & getrecommendations! Published in 2019 at "European journal of endocrinology"
DOI: 10.1530/eje-19-0458
Abstract: Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in such a way that clinical… read more here.
Keywords: igf igf; igf; performance; fit purpose ... See more keywords
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
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DOI: 10.3389/fonc.2021.755341
Abstract: Aim Insulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of… read more here.
Keywords: high expression; igf igf; igf; cancer ... See more keywords
Jinmaitong, a Traditional Chinese Compound Prescription, Ameliorates the Streptozocin-Induced Diabetic Peripheral Neuropathy Rats by Increasing Sciatic Nerve IGF-1 and IGF-1R Expression
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00255
Abstract: Jinmaitong (JMT) is a Traditional Chinese Compound Prescription for the treatment of diabetic peripheral neuropathy (DPN). This study aims to investigate the effect of JMT on the insulin-like growth factor 1 (IGF-1) and the insulin… read more here.
Keywords: igf igf; traditional chinese; jmt; chinese compound ... See more keywords
The Role of IGF/IGF-1R Signaling in Hepatocellular Carcinomas: Stemness-Related Properties and Drug Resistance
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DOI: 10.3390/ijms22041931
Abstract: Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem cell pluripotency and differentiation to trigger cell proliferation, organ development, and tissue regeneration during embryonic development. Unbalanced IGF/IGF-1R signaling can promote cancer cell… read more here.
Keywords: drug resistance; igf igf; igf signaling; igf ... See more keywords
Age-dependent decreases in insulin-like growth factor-I and its receptor expressions in the gerbil olfactory bulb
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DOI: 10.3892/mmr.2018.8886
Abstract: Insulin-like growth factor-I (IGF-I) is a multifunctional protein present in the central nervous system. A number of previous studies have revealed alterations in IGF-I and its receptor (IGF-IR) expression in various regions of the brain.… read more here.
Keywords: age; igf igf; group; olfactory bulb ... See more keywords
Clinicopathological significance and impact on outcomes of the gene expression levels of IGF-1, IGF-2 and IGF-1R, IGFBP-3 in patients with colorectal cancer: Overexpression of the IGFBP-3 gene is an effective predictor of outcomes in patients with colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5936
Abstract: The insulin-like growth factors (IGF) system is involved in tumor proliferation, invasion and metastasis in cancer. The current study investigated the association of IGF-1, IGF-2 and IGF-1 receptor (IGF-1R), IGF binding proteins type 3 (IGFBP-3)… read more here.
Keywords: igf igf; gene expression; expression; cancer ... See more keywords