Rab9‐dependent autophagy is required for the IGF‐IIR triggering mitophagy to eliminate damaged mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26346
Abstract: Mitochondria dysfunction is the major characteristic of mitophagy, which is essential in mitochondrial quality control. However, excessive mitophagy contributes to cell death in a number of diseases, including ischemic stroke and hepatotoxicity. Insulin‐like growth factor… read more here.
Keywords: iir; autophagy required; dependent autophagy; igf iir ... See more keywords
The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF‐IIR‐induced cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29242
Abstract: Cardiac hypertrophy is a common phenomenon observed in progressive heart disease associated with heart failure. Insulin‐like growth factor receptor II (IGF‐IIR) has been much implicated in myocardial hypertrophy. Our previous studies have found that increased… read more here.
Keywords: camkii calcineurin; hypertrophy; igf iir;
Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.04.008
Abstract: Abstract Hypertension is a progressive condition. The compensatory left ventricular hypertrophy maintains cardiac output. It leads to myocardial remodeling characterized by fibrosis, insufficient vascularization, even apoptosis and heart failure. This condition involves a possible mechanism… read more here.
Keywords: apoptosis; sirt1 hsf1; jnk sirt1; igf iir ... See more keywords