Up‐regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR‐182‐5p/IGF1 axis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11333
Abstract: Long non‐coding RNA (lncRNA) SNHG16 has been reported to be significant regulators in multiple cancers. However, never has the relationship between it and cardiac hypertrophy been studied until now. In this study, angiotensin II (Ang… read more here.
Keywords: cardiac hypertrophy; mir 182; igf1; expression ... See more keywords
Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production
Sign Up to like & getrecommendations! Published in 2025 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.3906
Abstract: Signaling networks can be used to describe the dynamic interplay of hormonal and mechanical factors that regulate heart growth. However, a qualitative analysis of signaling networks is often difficult due to their complexity and nonlinear… read more here.
Keywords: growth; igf1; sensitivity analysis; heart growth ... See more keywords
Igf1 Regulates Fibrocartilage Stem Cells, Cartilage Growth, and Homeostasis in the Temporomandibular Joint of Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4782
Abstract: Temporomandibular joint (TMJ) growth requires orchestrated interactions between various cell types. Recent studies revealed that fibrocartilage stem cells (FCSCs) in the TMJ cartilage play critical roles as cell resources for joint development and repair. However,… read more here.
Keywords: cell; deletion; igf1; cartilage ... See more keywords
Soluble expression of IGF1 fused to DsbA in SHuffle™ T7 strain: optimization of expression and purification by Box-Behnken design
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09719-w
Abstract: Production of insulin-like growth factor 1 (IGF1) in Escherichia coli mostly results in the formation of inclusion bodies. In the present study, IGF1 was fused to disulfide bond oxidoreductase A (DsbA) and expressed in SHuffle™… read more here.
Keywords: dsba; igf1; expression; optimization ... See more keywords
The role of IGF1 in determining body composition in children and adolescents with growth hormone deficiency and those with idiopathic short stature
Sign Up to like & getrecommendations! Published in 2024 at "Endocrine"
DOI: 10.1007/s12020-024-03992-0
Abstract: Treatment with recombinant human growth hormone (rhGH) increases insulin growth factor-1 (IGF1) levels, therefore, monitoring both IGF1 and growth constitutes an acceptable parameter of therapeutic safety and efficacy. We aimed to investigate the relationship between… read more here.
Keywords: growth hormone; growth; body composition; igf1 ... See more keywords
Randomized placebo controlled trial evaluating the safety and efficacy of single low‐dose intracoronary insulin‐like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS‐AMI)
Sign Up to like & getrecommendations! Published in 2018 at "American Heart Journal"
DOI: 10.1016/j.ahj.2018.03.018
Abstract: Background: Residual and significant postinfarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST‐elevation myocardial infarction (STEMI), remains an important clinical issue. In preclinical models, low‐dose insulin‐like growth factor 1 (IGF1)… read more here.
Keywords: low dose; end; safety; igf1 ... See more keywords
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.03.032
Abstract: ABSTRACT Sensorineural hearing loss (SNHL) is mainly caused by the damage of cochlear hair cells (HCs). As HCs and supporting cells (SCs) do not proliferate in postnatal mammals, the loss of HCs and SCs is… read more here.
Keywords: hair cells; hair; insulin like; igf1 ... See more keywords
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.03.017
Abstract: Decline in hematopoietic stem cell (HSC) function with age underlies limited health span of our blood and immune systems. In order to preserve health into older age, it is necessary to understand the nature and… read more here.
Keywords: decline; stem cell; hematopoietic stem; igf1 ... See more keywords
Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07857-y
Abstract: Insulin-like growth factor-binding protein 5 (IGFBP5) is associated with nonalcoholic fatty liver disease (NAFLD). IGFBP5 has a higher binding affinity to IGF1 and modulates its effects in serum. However, the effect of exercise on its… read more here.
Keywords: igfbp5 igf1; igf1 ratio; nonalcoholic fatty; igf1 ... See more keywords
MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2020.1728210
Abstract: Abstract Background This study explored the function and mechanism of miR-486-5p in HSFBs. Methods Qualitative real-time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-486-5p in HS and hypertrophic scar fibroblasts (HSFBs). Viability,… read more here.
Keywords: collagen; pi3k akt; hsfbs; igf1 ... See more keywords
miR-29a-3p mitigates the development of osteosarcoma through modulating IGF1 mediated PI3k/Akt/FOXO3 pathway by activating autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2078614
Abstract: ABSTRACT Osteosarcoma (OS), occurring in mesenchymal tissues and with a high degree of malignancy, is most common in children and adolescents. At present, we intend to figure out the expression and functions of miR-29a-3p in… read more here.
Keywords: pi3k akt; igf1; akt foxo3; mir 29a ... See more keywords