Up‐regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR‐182‐5p/IGF1 axis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11333
Abstract: Long non‐coding RNA (lncRNA) SNHG16 has been reported to be significant regulators in multiple cancers. However, never has the relationship between it and cardiac hypertrophy been studied until now. In this study, angiotensin II (Ang… read more here.
Keywords: cardiac hypertrophy; mir 182; igf1; expression ... See more keywords
Igf1 Regulates Fibrocartilage Stem Cells, Cartilage Growth, and Homeostasis in the Temporomandibular Joint of Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4782
Abstract: Temporomandibular joint (TMJ) growth requires orchestrated interactions between various cell types. Recent studies revealed that fibrocartilage stem cells (FCSCs) in the TMJ cartilage play critical roles as cell resources for joint development and repair. However,… read more here.
Keywords: cell; deletion; igf1; cartilage ... See more keywords
Soluble expression of IGF1 fused to DsbA in SHuffle™ T7 strain: optimization of expression and purification by Box-Behnken design
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09719-w
Abstract: Production of insulin-like growth factor 1 (IGF1) in Escherichia coli mostly results in the formation of inclusion bodies. In the present study, IGF1 was fused to disulfide bond oxidoreductase A (DsbA) and expressed in SHuffle™… read more here.
Keywords: dsba; igf1; expression; optimization ... See more keywords
Randomized placebo controlled trial evaluating the safety and efficacy of single low‐dose intracoronary insulin‐like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS‐AMI)
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DOI: 10.1016/j.ahj.2018.03.018
Abstract: Background: Residual and significant postinfarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST‐elevation myocardial infarction (STEMI), remains an important clinical issue. In preclinical models, low‐dose insulin‐like growth factor 1 (IGF1)… read more here.
Keywords: low dose; end; safety; igf1 ... See more keywords
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.03.032
Abstract: ABSTRACT Sensorineural hearing loss (SNHL) is mainly caused by the damage of cochlear hair cells (HCs). As HCs and supporting cells (SCs) do not proliferate in postnatal mammals, the loss of HCs and SCs is… read more here.
Keywords: hair cells; hair; insulin like; igf1 ... See more keywords
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.03.017
Abstract: Decline in hematopoietic stem cell (HSC) function with age underlies limited health span of our blood and immune systems. In order to preserve health into older age, it is necessary to understand the nature and… read more here.
Keywords: decline; stem cell; hematopoietic stem; igf1 ... See more keywords
MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2020.1728210
Abstract: Abstract Background This study explored the function and mechanism of miR-486-5p in HSFBs. Methods Qualitative real-time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-486-5p in HS and hypertrophic scar fibroblasts (HSFBs). Viability,… read more here.
Keywords: collagen; pi3k akt; hsfbs; igf1 ... See more keywords
miR-29a-3p mitigates the development of osteosarcoma through modulating IGF1 mediated PI3k/Akt/FOXO3 pathway by activating autophagy
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DOI: 10.1080/15384101.2022.2078614
Abstract: ABSTRACT Osteosarcoma (OS), occurring in mesenchymal tissues and with a high degree of malignancy, is most common in children and adolescents. At present, we intend to figure out the expression and functions of miR-29a-3p in… read more here.
Keywords: pi3k akt; igf1; akt foxo3; mir 29a ... See more keywords
FRI0028 LOW SERUM IGF1 IS ASSOCIATED WITH AN INCREASED RISK AND HIGH PREVALENCE OF CARDIOVASCULAR EVENTS IN MIDDLE-AGED FEMALE PATIENTS WITH RA – A 5-YEAR FOLLOW-UP
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4759
Abstract: Background: Recent meta-analysis reported that rheumatoid arthritis (RA) is associated with high frequency of hypertension and stroke (1). IGF1 is an important angioprotector and its deficiency predisposes to development of ischemic stroke (2). Objectives: Since… read more here.
Keywords: low igf1; female patients; prevalence; igf1 associated ... See more keywords
Abstract 2371: Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor initiated oncogenesis through IGFBP3 mediated IGF1 induced Wnt activation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2371
Abstract: Prostate cancer is the second most common cancer in men worldwide. The current treatment targeting androgen receptor (AR) expressing cells, androgen deprivation therapy (ADT), eventually fails in most prostate cancer patients who consequently develop castration… read more here.
Keywords: igfbp3; igf1; gli1 lineage; tumor ... See more keywords
Crosstalk between the IGF1 and CXCL12 Pathways Defines Objective Responses to the Farnesyl Transferase Inhibitor Tipifarnib in AML and PTCL Patients
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DOI: 10.1182/blood-2018-99-116969
Abstract: Background CXCL12 is a chemokine that is essential for the maturation of myeloid and lymphoid cells. Tipifarnib is a potent and selective inhibitor of the enzyme farnesyltransferase (FT). Treatment with this agent may translate to… read more here.
Keywords: igf1 cxcl12; objective responses; igf1; expression ... See more keywords