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   Articles with "igf1r" as a keyword



Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor

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recommendations! Published in 2021 at "Journal of Ginseng Research"

DOI: 10.1016/j.jgr.2021.08.005

Abstract: Abstract Background During the pathogenesis of tendinopathy, the chronic inflammation caused by the injury and apoptosis leads to the generation of scars. Ginsenoside Rg1 (Rg1) is extracted from ginseng and has anti-inflammatory effects. Rg1 is… read more here.

Keywords: ginsenoside rg1; rg1; achilles tendinitis; igf1r ... See more keywords
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Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

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recommendations! Published in 2018 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.07.029

Abstract: Highlights • We have established a novel human astrocyte-neuron co-culture system.• Astrocytes provided contact-mediated support for neurite outgrowth.• IGF1R-impaired astrocytes are less able to protect neurons under stress conditions.• Microarray analysis of these astrocytes identified… read more here.

Keywords: loss igf1r; human astrocytes; astrocytes alters; igf1r ... See more keywords

Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-04304-5

Abstract: Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhibitor of… read more here.

Keywords: liver steatosis; recovery; osi 906; cell proliferation ... See more keywords

Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep44473

Abstract: Microcirculatory dysfunction is believed to play an important role in diabetic cardiomyopathy. The small leucine-rich proteoglycan decorin is generally considered a pro-angiogenic factor. Here, we investigate whether overexpression of decorin ameliorates diabetic cardiomyopathy and its… read more here.

Keywords: overexpression decorin; overexpression; vegf; igf1r ... See more keywords

The in vitro and in vivo antiviral effects of IGF1R inhibitors against respiratory syncytial virus infection

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recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2024.2309643

Abstract: Abstract The insulin-like growth factor 1 receptor (IGF1R) was recognized as a pivotal receptor that facilitated the cellular entry of RSV. Small molecule inhibitors designed to target IGF1R exhibited potential as potent antiviral agents. Through… read more here.

Keywords: igf1r; respiratory syncytial; syncytial virus; infection ... See more keywords

Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.

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recommendations! Published in 2018 at "DNA and cell biology"

DOI: 10.1089/dna.2018.4336

Abstract: Grb10 (growth factor receptor-bound protein 10)-interacting GYF protein 1 (GIGYF1) can modulate insulin-like growth factor 1 receptor (IGF1R) signaling pathway, which plays an important role in regulating diabetes-associated cognitive impairment, by linking to Grb10 adapter.… read more here.

Keywords: shsy cells; signaling pathway; high glucose; igf1r signaling ... See more keywords

DDDR-49. IGF1R inhibition arrests meningioma growth

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0686

Abstract: Meningiomas are the most common primary tumors of the central nervous system. While standard-of-care treatment—surgical resection and/or radiotherapy—is effective for most patients, a subset of tumors progress despite these interventions. To identify novel therapeutic targets,… read more here.

Keywords: igf1r; inhibition; cell; igf2 igf1r ... See more keywords

[PP.19.15] RETINAL ARTERIOLES HYPERTROPHIC REMODELING IN UNCONTROLLED ACROMEGALY

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recommendations! Published in 2017 at "Journal of Hypertension"

DOI: 10.1097/01.hjh.0000523706.72591.49

Abstract: Objective: Acromegaly is characterized by an increased cardiovascular risk. Hypertrophic effects of Growth Hormone (GH)/Insulin-like Growth Factor 1 (IGF1) system on the heart and large arteries are known but little data on microcirculation exist. Our… read more here.

Keywords: hypertrophic remodeling; controlled acromegaly; uncontrolled acromegaly; optics ... See more keywords

Adipocyte‐specific IGF1R knockout activates the β‐catenin/apelin axis to combat diet‐induced obesity in male mice

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recommendations! Published in 2025 at "Diabetes"

DOI: 10.1111/dom.70091

Abstract: Obesity, driven by complex genetic and environmental interactions, remains a global health crisis with limited therapeutic options. The insulin‐like growth factor 1 receptor (IGF1R) plays dual roles in metabolism and growth, but its tissue‐specific functions… read more here.

Keywords: igf1r; knockout activates; adipocyte specific; igf1r knockout ... See more keywords

Igf1r signalling acts on the anagen‐to‐catagen transition in the hair cycle

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recommendations! Published in 2017 at "Experimental Dermatology"

DOI: 10.1111/exd.13287

Abstract: Insulin‐like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and… read more here.

Keywords: hair cycle; igf1r; mice; k15 igf1rko ... See more keywords

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-18-0372

Abstract: Purpose: Novel targeted therapeutics have transformed the care of subsets of patients with cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent targetable mutations, there have been few new FDA-approved targeted drugs. The… read more here.

Keywords: inhibitor; cdk4; cdk4 inhibitors; ewing sarcoma ... See more keywords