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   Articles with "igf1r" as a keyword



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Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor

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recommendations! Published in 2021 at "Journal of Ginseng Research"

DOI: 10.1016/j.jgr.2021.08.005

Abstract: Abstract Background During the pathogenesis of tendinopathy, the chronic inflammation caused by the injury and apoptosis leads to the generation of scars. Ginsenoside Rg1 (Rg1) is extracted from ginseng and has anti-inflammatory effects. Rg1 is… read more here.

Keywords: ginsenoside rg1; rg1; achilles tendinitis; igf1r ... See more keywords
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Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

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recommendations! Published in 2018 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.07.029

Abstract: Highlights • We have established a novel human astrocyte-neuron co-culture system.• Astrocytes provided contact-mediated support for neurite outgrowth.• IGF1R-impaired astrocytes are less able to protect neurons under stress conditions.• Microarray analysis of these astrocytes identified… read more here.

Keywords: loss igf1r; human astrocytes; astrocytes alters; igf1r ... See more keywords
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Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-04304-5

Abstract: Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhibitor of… read more here.

Keywords: liver steatosis; recovery; osi 906; cell proliferation ... See more keywords

Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep44473

Abstract: Microcirculatory dysfunction is believed to play an important role in diabetic cardiomyopathy. The small leucine-rich proteoglycan decorin is generally considered a pro-angiogenic factor. Here, we investigate whether overexpression of decorin ameliorates diabetic cardiomyopathy and its… read more here.

Keywords: overexpression decorin; overexpression; vegf; igf1r ... See more keywords
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Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.

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recommendations! Published in 2018 at "DNA and cell biology"

DOI: 10.1089/dna.2018.4336

Abstract: Grb10 (growth factor receptor-bound protein 10)-interacting GYF protein 1 (GIGYF1) can modulate insulin-like growth factor 1 receptor (IGF1R) signaling pathway, which plays an important role in regulating diabetes-associated cognitive impairment, by linking to Grb10 adapter.… read more here.

Keywords: shsy cells; signaling pathway; high glucose; igf1r signaling ... See more keywords
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[PP.19.15] RETINAL ARTERIOLES HYPERTROPHIC REMODELING IN UNCONTROLLED ACROMEGALY

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recommendations! Published in 2017 at "Journal of Hypertension"

DOI: 10.1097/01.hjh.0000523706.72591.49

Abstract: Objective: Acromegaly is characterized by an increased cardiovascular risk. Hypertrophic effects of Growth Hormone (GH)/Insulin-like Growth Factor 1 (IGF1) system on the heart and large arteries are known but little data on microcirculation exist. Our… read more here.

Keywords: hypertrophic remodeling; controlled acromegaly; uncontrolled acromegaly; optics ... See more keywords
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Igf1r signalling acts on the anagen‐to‐catagen transition in the hair cycle

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recommendations! Published in 2017 at "Experimental Dermatology"

DOI: 10.1111/exd.13287

Abstract: Insulin‐like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and… read more here.

Keywords: hair cycle; igf1r; mice; k15 igf1rko ... See more keywords
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A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-18-0372

Abstract: Purpose: Novel targeted therapeutics have transformed the care of subsets of patients with cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent targetable mutations, there have been few new FDA-approved targeted drugs. The… read more here.

Keywords: inhibitor; cdk4; cdk4 inhibitors; ewing sarcoma ... See more keywords
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Abstract 4823: The novel miR-15a/Fra-2/IGF1R axis drives response to starvation-induced cell stress in pancreatic ductal adenocarcinoma

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-4823

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon malignancy; however, its incidence is rising worldwide, and it is expected to become the second-leading cause of cancer-related death by 2030. From a histological point of view,… read more here.

Keywords: fra; cell; mir 15a; starvation ... See more keywords
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Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies

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recommendations! Published in 2017 at "Hormone Research in Paediatrics"

DOI: 10.1159/000464143

Abstract: Background: The growth-promoting effects of IGF-I is mediated through the IGF-I receptor (IGF1R), a widely expressed cell-surface tyrosine kinase receptor. IGF1R copy number variants (CNV) can cause pre- and postnatal growth restriction or overgrowth. Methods:… read more here.

Keywords: live primary; igf1r; facs analysis; cell surface ... See more keywords
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SM22&agr; (Smooth Muscle Protein 22-&agr;) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis

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recommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.118.311134

Abstract: Objective— IGF-1 (insulin-like growth factor 1) is a major autocrine/paracrine growth factor, which promotes cell proliferation, migration, and survival. We have shown previously that IGF-1 reduced atherosclerosis and promoted features of stable atherosclerotic plaque in… read more here.

Keywords: igf1r; smooth muscle; sm22 agr; mice ... See more keywords