IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis.
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DOI: 10.1016/j.ydbio.2020.04.007
Abstract: Breast tumors display tremendous heterogeneity in part due to varying molecular alterations, divergent cells of origin, and differentiation. Understanding where and how this heterogeneity develops is likely important for effective breast cancers eradication. Insulin-like growth… read more here.
Keywords: lineage differentiation; differentiation; constitutive activation; igf1r constitutive ... See more keywords