IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model
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DOI: 10.1038/s41598-017-04561-4
Abstract: IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is implicated in pulmonary diseases such as cancer, ARDS, COPD, asthma and fibrosis. Here… read more here.
Keywords: bleomycin induced; induced lung; lung injury; igf1r deficiency ... See more keywords
IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis
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DOI: 10.3390/biomedicines9020158
Abstract: Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system, including neurogenesis, synaptic plasticity and complex cognitive functions. In the present study, we intended to characterize the impact… read more here.
Keywords: homeostasis; signaling pathways; brain; igf1r deficiency ... See more keywords