IGF1R expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation
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DOI: 10.1002/glia.24299
Abstract: In the central nervous system (CNS), insulin‐like growth factor 1 (IGF‐1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti‐apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work… read more here.
Keywords: neuroinflammation; igf1r expression; odcs; absence igf1r ... See more keywords
Association between insulin-like growth factor-1 receptor (IGF1R) expression in circulating tumor cells (CTCs) and prognosis in patients with metastatic breast cancer (MBC).
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DOI: 10.1200/jco.2017.35.15_suppl.1086
Abstract: 1086Background: CTCs are strongly associated with prognosis in MBC. In a recent metanalysis on 1944 patients, a CTC count > 5/7.5 ml was associated with a 2-fold increased risk of progression and death. Little evidence… read more here.
Keywords: growth; prognosis; mbc; igf1r expression ... See more keywords