Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22994
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease with the formation and accumulation of macrophage-derived foam cells in the subendothelial space of blood vessels as one major characteristic. Insulin-like growth factor 2 messenger RNA (mRNA) binding… read more here.
Keywords: expression; accumulation; silencing igf2bp1; lipid accumulation ... See more keywords
LncRNA PCAT6 Regulated by YY1 Accelerates the Progression of Glioblastoma via miR-513/IGF2BP1.
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical research"
DOI: 10.1007/s11064-020-03138-4
Abstract: Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but… read more here.
Keywords: mir 513; glioblastoma; pcat6; expression ... See more keywords
Insights into genetic variants within sheep IGF2BP1 and their association with litter size
Sign Up to like & getrecommendations! Published in 2021 at "Small Ruminant Research"
DOI: 10.1016/j.smallrumres.2021.106350
Abstract: Abstract Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays a crucial role in cellular growth, proliferation, and embryonic development by regulating mRNA stability. IGF2BP1 has been recently found to be located on a new… read more here.
Keywords: association; litter size; indel; igf2bp1 ... See more keywords
Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c00107
Abstract: Tumor immune microenvironment (TIME) regulators are promising cancer immunotherapeutic targets. IGF2BP1, as a crucial N6-methyladenosine (m6A) reader protein, recognizes m6A target transcripts, ultimately leading to cancer development. However, currently, the biological function of IGF2BP1 in… read more here.
Keywords: allosteric regulation; immune microenvironment; tumor immune; tumor ... See more keywords
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0656-9
Abstract: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating potential,… read more here.
Keywords: stem cell; leukemia stem; cell; cell properties ... See more keywords
Novel IGF2BP1 splice variants, expression and their association with growth traits in goose
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2094220
Abstract: ABSTRACT 1. The gene IGF2BP1 has been reported as being related to the body size and body weight in ducks, goats and chickens. However, this potential growth-related gene has not yet been reported in geese.… read more here.
Keywords: goose igf2bp1; novel igf2bp1; igf2bp1 splice; growth ... See more keywords
METTL21C mediates lysine trimethylation of IGF2BP1 to regulate chicken myoblast proliferation
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2121639
Abstract: ABSTRACT 1. Methyltransferase-like 21C (METTL21C) and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) play important roles in the proliferation of chicken myoblasts. However, it remains unclear whether there is protein-protein interaction between METTL21C and… read more here.
Keywords: igf2bp1 regulate; proliferation; chicken; protein ... See more keywords
IGF2BP1 promotes the liver cancer stem cell phenotype by regulating MGAT5 mRNA stability via m6A RNA methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0153
Abstract: The aim of this study was to elucidate the mechanism of action of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells (LCSCs). To gain insight… read more here.
Keywords: mgat5; mrna stability; via m6a; stem ... See more keywords
Regulation of IGF2BP1 by miR-186 and its impact on downstream lncRNAs H19, FOXD2-AS1, and SNHG3 in HCC.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4128906
Abstract: AIM We have previously characterized oncogenic properties of IGF2BP1 in HCC, and its regulation by short noncoding RNAs (ncRNAs). Recent evidence suggests that IGF2BP1 itself may regulate long ncRNAs (lncRNAs). Therefore, this study aimed at… read more here.
Keywords: foxd2 as1; lncrnas h19; mir 186; igf2bp1 ... See more keywords
Elevated insulin-like growth factor 2 mRNA binding protein 1 levels predict a poor prognosis in patients with breast carcinoma using an integrated multi-omics data analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.994003
Abstract: Background: Insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) controls the cytoplasmic fate of certain mRNAs and is hypothesized to predict a poor patient prognosis in several malignant tumors. However, the prognostic relevance of… read more here.
Keywords: prognosis; predict poor; insulin like; like growth ... See more keywords
IGF2BP1, a Conserved Regulator of RNA Turnover in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.632219
Abstract: The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) promotes tumor progression in a variety of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the… read more here.
Keywords: cancer; target mrnas; igf2bp1; igf2bp1 rna ... See more keywords