Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22994
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease with the formation and accumulation of macrophage-derived foam cells in the subendothelial space of blood vessels as one major characteristic. Insulin-like growth factor 2 messenger RNA (mRNA) binding… read more here.
Keywords: expression; accumulation; silencing igf2bp1; lipid accumulation ... See more keywords
The RNA‐Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.70016
Abstract: Insulin‐like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a key reader of N6‐methyladenosine modifications that regulate target mRNA stability in eukaryotic cells; however, its role in germ cells has never been explored. Here,… read more here.
Keywords: protein igf2bp1; germ cells; igf2bp1; binding protein ... See more keywords
LncRNA PCAT6 Regulated by YY1 Accelerates the Progression of Glioblastoma via miR-513/IGF2BP1.
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical research"
DOI: 10.1007/s11064-020-03138-4
Abstract: Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but… read more here.
Keywords: mir 513; glioblastoma; pcat6; expression ... See more keywords
Insights into genetic variants within sheep IGF2BP1 and their association with litter size
Sign Up to like & getrecommendations! Published in 2021 at "Small Ruminant Research"
DOI: 10.1016/j.smallrumres.2021.106350
Abstract: Abstract Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays a crucial role in cellular growth, proliferation, and embryonic development by regulating mRNA stability. IGF2BP1 has been recently found to be located on a new… read more here.
Keywords: association; litter size; indel; igf2bp1 ... See more keywords
Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c00107
Abstract: Tumor immune microenvironment (TIME) regulators are promising cancer immunotherapeutic targets. IGF2BP1, as a crucial N6-methyladenosine (m6A) reader protein, recognizes m6A target transcripts, ultimately leading to cancer development. However, currently, the biological function of IGF2BP1 in… read more here.
Keywords: allosteric regulation; immune microenvironment; tumor immune; tumor ... See more keywords
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0656-9
Abstract: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating potential,… read more here.
Keywords: stem cell; leukemia stem; cell; cell properties ... See more keywords
Novel IGF2BP1 splice variants, expression and their association with growth traits in goose
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2094220
Abstract: ABSTRACT 1. The gene IGF2BP1 has been reported as being related to the body size and body weight in ducks, goats and chickens. However, this potential growth-related gene has not yet been reported in geese.… read more here.
Keywords: goose igf2bp1; novel igf2bp1; igf2bp1 splice; growth ... See more keywords
METTL21C mediates lysine trimethylation of IGF2BP1 to regulate chicken myoblast proliferation
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2121639
Abstract: ABSTRACT 1. Methyltransferase-like 21C (METTL21C) and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) play important roles in the proliferation of chicken myoblasts. However, it remains unclear whether there is protein-protein interaction between METTL21C and… read more here.
Keywords: igf2bp1 regulate; proliferation; chicken; protein ... See more keywords
IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Oncoimmunology"
DOI: 10.1080/2162402x.2025.2584408
Abstract: ABSTRACT The incorporation of the current immunotherapy, GD2-targeting monoclonal antibodies, into the standard of care has moderately improved clinical outcomes in children with high-risk neuroblastoma (HR-NB); however, overall survival remains low. More than 50% of… read more here.
Keywords: tumor microenvironment; immunotherapy; high risk; igf2bp1 ... See more keywords
IGF2BP1 promotes the liver cancer stem cell phenotype by regulating MGAT5 mRNA stability via m6A RNA methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0153
Abstract: The aim of this study was to elucidate the mechanism of action of the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) on the phenotype of the liver cancer stem cells (LCSCs). To gain insight… read more here.
Keywords: mgat5; mrna stability; via m6a; stem ... See more keywords
Ligustrazine attenuates ferroptosis in proximal straight tubule cells via IGF2BP1-Odc1 regulation in a CKD model.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of surgery"
DOI: 10.1097/js9.0000000000004073
Abstract: BACKGROUND Chronic kidney disease (CKD) is a long-term progressive condition characterized by a decline in renal function, for which effective treatment strategies remain limited. This study aimed to evaluate the effectiveness of ligustrazine for CKD… read more here.
Keywords: ckd; ligustrazine; ferroptosis; igf2bp1 ... See more keywords