Reply to the Comment on “The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ”
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201452
Abstract: We thank Schymik et al.[1] for their interest in our article published in the July 2021 issue.[2] They raised several interesting points that we would like to address. First, the concern “in human monocyte-derived macrophages… read more here.
Keywords: lps treatment; igf2bp2; regulates macrophage; activation ... See more keywords
IGF2BP2, an RNA‐binding protein regulates cell proliferation and osteogenic differentiation by stabilizing SRF mRNA
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30919
Abstract: Osteoblast proliferation and osteogenic differentiation (OGD) are regulated by complex mechanisms. The roles in cell proliferation and OGD of RNA‐binding proteins in the insulin‐like growth factor 2 mRNA‐binding protein (IGF2BP) family remain unclear. To elucidate… read more here.
Keywords: cell proliferation; proliferation osteogenic; proliferation; rna ... See more keywords
An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs
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DOI: 10.1016/j.isci.2021.103680
Abstract: Summary lncRAP2 is a conserved cytoplasmic lncRNA enriched in adipose tissue and required for adipogenesis. Using purification and in vivo interactome analyses, we show that lncRAP2 forms complexes with proteins that stabilize mRNAs and modulate… read more here.
Keywords: igf2bp2 complex; igf2bp2; lncrap2 igf2bp2; energy expenditure ... See more keywords
IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
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DOI: 10.1038/s41418-019-0461-z
Abstract: The major function of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is to regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role in cancer, but the underlying mechanism is largely unknown.… read more here.
Keywords: regulates dancr; methyladenosine; igf2bp2 regulates; cancer ... See more keywords
IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma
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DOI: 10.1042/bsr20212119
Abstract: Abstract Aim: The main of the present study was to investigate the role of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) in oral squamous cell carcinoma (OSCC) with the overarching of providing new biomarkers… read more here.
Keywords: cell carcinoma; igf2bp2 expression; squamous cell; expression ... See more keywords
Hsa_circ_0001756 promotes ovarian cancer progression through regulating IGF2BP2-mediated RAB5A expression and the EGFR/MAPK signaling pathway
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DOI: 10.1080/15384101.2021.2010166
Abstract: ABSTRACT Hsa_circ_0001756 was reported to be upregulated in serum samples of ovarian cancer (OC) patients and may serve as a potential OC biomarker. This study aimed to investigate the role and molecular mechanisms of hsa_circ_0001756… read more here.
Keywords: igf2bp2; circ 0001756; expression; hsa circ ... See more keywords
Targeting PD-L1 (Programmed death-ligand 1) and inhibiting the expression of IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2) affect the proliferation and apoptosis of hypopharyngeal carcinoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1983278
Abstract: Programmed cell death-ligand 1 (PD-L1) have been attracting increasing attention in cancer diagnosis and treatment. The insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is involved in the progression of multiple types of cancer. So,… read more here.
Keywords: hypopharyngeal carcinoma; carcinoma; apoptosis; expression ... See more keywords
N6-methyladenosine (m6A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1
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DOI: 10.1080/21655979.2022.2068920
Abstract: ABSTRACT N6-methyladenosine (m6A) modification acts as the most prevalent internal modification in eukaryotic mRNA. Emerging evidence shows the critical biological roles of m6A key enzymes in human cancers. However, the roles of m6A binding protein… read more here.
Keywords: cancer progression; methyladenosine m6a; igf2bp2; gastric cancer ... See more keywords
The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
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DOI: 10.1186/s12935-021-01799-x
Abstract: The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene. Indeed IGF2BP2… read more here.
Keywords: human metabolic; igf2bp2; metabolic diseases; m6a reader ... See more keywords
Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer's disease.
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DOI: 10.18632/aging.203652
Abstract: Alzheimer's disease, the most common form of dementia in the elderly, is a kind of neurodegenerative disease. However, its pathogenesis and diagnosis remain unclear. M6A is related to nervous system development and neurodegenerative diseases. Here… read more here.
Keywords: alzheimer disease; igf2bp2; disease; m6a reader ... See more keywords
IGF2BP2 Induces U251 Glioblastoma Cell Chemoresistance by Inhibiting FOXO1-Mediated PID1 Expression Through Stabilizing lncRNA DANCR
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DOI: 10.3389/fcell.2021.659228
Abstract: Glioma is the most common type of malignant tumor of the nervous system and is characterized by high mortality and poor outcome. This study aims to investigate the mechanism underlying IGF2 mRNA-binding protein 2 (IGF2BP2)… read more here.
Keywords: dancr; expression; igf2bp2; foxo1 ... See more keywords