Insulin‐like growth factor‐2 mRNA‐binding protein 3 promotes cell migration, invasion, and epithelial−mesenchymal transition of esophageal squamous cell carcinoma cells by targeting zinc finger E‐box‐binding homeobox 1 mRNA
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23502
Abstract: The role and mechanism of insulin‐like growth factor‐2 mRNA‐binding protein 3 (IGF2BP3) in the metastasis of esophageal squamous cell carcinoma (ESCC) remain unclear. In this study, IGF2BP3 mRNA and protein expression levels were evaluated in… read more here.
Keywords: cell; igf2bp3; insulin like; escc ... See more keywords
Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.12.061
Abstract: Background The cross-talk between RNA binding proteins (RBPs) and microRNAs (miRNAs) in the regulation of gene expression is a complex process. Here, we describe a new mode of regulation of TRIM25 expression mediated by an… read more here.
Keywords: mir; igf2bp3; breast cancer; expression ... See more keywords
IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2150636
Abstract: Abstract Objectives The tumor-promoting function of IGF2BP3 has been reported in several cancers. The present study aimed to explore the function and molecular mechanisms of IGF2BP3 are elusive in lung adenocarcinoma (LUAD). Methods IGF2BP3 expression… read more here.
Keywords: pi3k akt; igf2bp3; lung adenocarcinoma; expression ... See more keywords
Abnormal Expression of N6-Methyladenosine RNA Methylation Regulator IGF2BP3 in Colon Cancer Predicts a Poor Prognosis
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DOI: 10.1155/2022/5883101
Abstract: The value of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an N6-methyladenosine (m6A) RNA methylation regulatory factor, in the prognosis of colon cancer was still unclear. High levels of IGF2BP3 were expressed in colon… read more here.
Keywords: rna methylation; igf2bp3; expression; colon cancer ... See more keywords
Abstract 3672: Insulin-like growth factor 2 (IGF-2) mRNA binding protein 3-mediated regulation of CD164-CXCR4 axis impacts aggressiveness of Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3672
Abstract: INTRODUCTION: The genomic stability of primary and metastatic Ewing sarcoma (EWS), the second most common primary bone tumor in pediatric age, evokes epigenetic or mRNA translational reprogramming as mechanisms involved in tumor progression. The oncofetal… read more here.
Keywords: growth; cxcr4; cd164; cd164 cxcr4 ... See more keywords
N6-methyladenosine reader IGF2BP3 as a prognostic Biomarker contribute to malignant progression of glioma
Sign Up to like & getrecommendations! Published in 2023 at "Translational Cancer Research"
DOI: 10.21037/tcr-23-449
Abstract: Background Glioblastoma (GBM) is a highly aggressive cancer having a dismal prognosis. N6-methyladenosine (m6A) is closely related to GBM progression. The significance of m6A modifications depends on the m6A readers, whose functions in glioma progression… read more here.
Keywords: cell; cycle; igf2bp3; progression ... See more keywords
Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis
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DOI: 10.3389/fonc.2020.00994
Abstract: Ewing sarcoma (EWS) is the second most common bone and soft tissue-associated malignancy in children and young adults. It is driven by the fusion oncogene EWS/FLI1 and characterized by rapid growth and early metastasis. We… read more here.
Keywords: growth; expression; cd164 cxcr4; igf2bp3 ... See more keywords
Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer
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DOI: 10.3389/fonc.2021.711207
Abstract: Hypoxia is a common feature of solid tumors including stomach cancer (SC) and is closely associated with cancer malignant progression. N6-methyladenosine (m6A), a common modification on RNA, is involved in the regulation of RNA fate… read more here.
Keywords: migration angiogenesis; cell migration; igf2bp3; hypoxia ... See more keywords
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
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DOI: 10.3390/cancers13071505
Abstract: Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3,… read more here.
Keywords: risk; igf2bp3; lymphoblastic leukemia; expression ... See more keywords
IGF2BP3-stabilized SIX4 promotes the proliferation, migration, invasion and tube formation of ovarian cancer cells
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DOI: 10.3892/mmr.2022.12748
Abstract: The mortality rate of ovarian cancer (OC) is the highest among the different types of female reproductive system cancers. SIX homeobox 4 (SIX4), a member of the homeobox family, subfamily SIX, fulfills an important role… read more here.
Keywords: igf2bp3; migration; invasion; formation ... See more keywords