Insulin‐like growth factor‐2 mRNA‐binding protein 3 promotes cell migration, invasion, and epithelial−mesenchymal transition of esophageal squamous cell carcinoma cells by targeting zinc finger E‐box‐binding homeobox 1 mRNA
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23502
Abstract: The role and mechanism of insulin‐like growth factor‐2 mRNA‐binding protein 3 (IGF2BP3) in the metastasis of esophageal squamous cell carcinoma (ESCC) remain unclear. In this study, IGF2BP3 mRNA and protein expression levels were evaluated in… read more here.
Keywords: cell; igf2bp3; insulin like; escc ... See more keywords
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23802
Abstract: Vascular endothelial growth factor A (VEGFA) plays a critical role as a potent angiogenesis factor and is highly expressed in hepatocellular carcinoma (HCC). Although the expression of VEGFA has been strongly linked to the aggressive… read more here.
Keywords: m6a; hcc; vegfa; hepatocellular carcinoma ... See more keywords
Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.12.061
Abstract: Background The cross-talk between RNA binding proteins (RBPs) and microRNAs (miRNAs) in the regulation of gene expression is a complex process. Here, we describe a new mode of regulation of TRIM25 expression mediated by an… read more here.
Keywords: mir; igf2bp3; breast cancer; expression ... See more keywords
The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer
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DOI: 10.1038/s42003-025-08065-0
Abstract: Paclitaxel combination therapy is the main chemotherapy regimen for endometrial cancer (EC); however, subsequent drug resistance is a bottleneck limiting its widespread clinical application. We found that human insulin-like growth factor 2 mRNA-binding protein 3… read more here.
Keywords: paclitaxel resistance; resistance; endometrial cancer; myc ... See more keywords
IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2150636
Abstract: Abstract Objectives The tumor-promoting function of IGF2BP3 has been reported in several cancers. The present study aimed to explore the function and molecular mechanisms of IGF2BP3 are elusive in lung adenocarcinoma (LUAD). Methods IGF2BP3 expression… read more here.
Keywords: pi3k akt; igf2bp3; lung adenocarcinoma; expression ... See more keywords
IGF2BP3 Triggers STAT3 Pathway by Stabilizing SRC RNA in an m6A‐Dependent Manner to Promote Lymphatic Metastasis in LUAD
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DOI: 10.1111/cas.16451
Abstract: Lymph node metastasis significantly affects the NSCLC patients' staging, treatment strategy, and prognosis. Studies have shown that IGF2BP3, an oncofetal protein and an m6A reader, overexpresses and correlates to lymph node metastasis and worse overall… read more here.
Keywords: m6a; metastasis luad; lymphatic metastasis; metastasis ... See more keywords
Abnormal Expression of N6-Methyladenosine RNA Methylation Regulator IGF2BP3 in Colon Cancer Predicts a Poor Prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/5883101
Abstract: The value of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an N6-methyladenosine (m6A) RNA methylation regulatory factor, in the prognosis of colon cancer was still unclear. High levels of IGF2BP3 were expressed in colon… read more here.
Keywords: rna methylation; igf2bp3; expression; colon cancer ... See more keywords
Abstract 3672: Insulin-like growth factor 2 (IGF-2) mRNA binding protein 3-mediated regulation of CD164-CXCR4 axis impacts aggressiveness of Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3672
Abstract: INTRODUCTION: The genomic stability of primary and metastatic Ewing sarcoma (EWS), the second most common primary bone tumor in pediatric age, evokes epigenetic or mRNA translational reprogramming as mechanisms involved in tumor progression. The oncofetal… read more here.
Keywords: growth; cxcr4; cd164; cd164 cxcr4 ... See more keywords
Novel Small Molecule Inhibitor Against IGF2BP3 with Potent Anti-Leukemic Activity
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DOI: 10.1182/blood-2024-204473
Abstract: Background:RNA binding proteins have emerged as promising therapeutic targets in cancer because of their role as important mediators of oncogenesis. The RNA binding protein IGF2BP3 is an oncofetal protein expressed during fetal development, absent or… read more here.
Keywords: mll; mll af4; i3in 002; igf2bp3 ... See more keywords
N6-methyladenosine reader IGF2BP3 as a prognostic Biomarker contribute to malignant progression of glioma
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DOI: 10.21037/tcr-23-449
Abstract: Background Glioblastoma (GBM) is a highly aggressive cancer having a dismal prognosis. N6-methyladenosine (m6A) is closely related to GBM progression. The significance of m6A modifications depends on the m6A readers, whose functions in glioma progression… read more here.
Keywords: cell; cycle; igf2bp3; progression ... See more keywords
Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00994
Abstract: Ewing sarcoma (EWS) is the second most common bone and soft tissue-associated malignancy in children and young adults. It is driven by the fusion oncogene EWS/FLI1 and characterized by rapid growth and early metastasis. We… read more here.
Keywords: growth; expression; cd164 cxcr4; igf2bp3 ... See more keywords