Prenatal arsenic exposure alters keratinocyte stem cell fate through persistent activation of IGF2R‐MAPK cascade leading to aggravated skin carcinogenesis in mice offspring
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23690
Abstract: Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal and early life exposure. In the present study, we demonstrate how only prenatal arsenic exposure… read more here.
Keywords: stem cell; exposure; igf2r; carcinogenesis ... See more keywords
Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1031210
Abstract: Background Laryngeal cancer (LC) is a prevalent head and neck malignancy; however, the essential pathophysiological mechanism underlying its tumorigenesis and progression remains elusive. Due to the perduring scarcity of effective targeted drugs for laryngeal cancer,… read more here.
Keywords: laryngeal cancer; analysis; igf2r; tumor ... See more keywords