Insulin‐like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3353
Abstract: Insulin‐like growth factor binding protein 4 (IGFBP‐4) was reported to trigger cellular senescence and reduce cell growth of bone marrow mesenchymal stem cells (BMSCs), but its contribution to neurogenic differentiation of BMSCs remains unknown. In… read more here.
Keywords: igfbp; stem cells; proliferation; growth ... See more keywords
CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12590
Abstract: Insulin‐like growth factor binding protein‐4 (IGFBP‐4) fragments have been shown to predict the risk of major adverse cardiovascular events, including segment‐elevation myocardial infarction, in patients with acute coronary syndrome. We evaluated the prognostic value of… read more here.
Keywords: failure igfbp; igfbp; acute heart; heart failure ... See more keywords
Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.02.015
Abstract: &NA; Insulin‐like growth factor 1 (IGF‐1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross‐sectionally, IGF‐1 decreases with age and levels of IGF‐1 are markedly… read more here.
Keywords: igfbp; age; clinic; igf igfbp ... See more keywords
Metabolic improvement after gastric bypass correlates with changes in IGF-regulatory proteins stanniocalcin-2 and IGFBP-4.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2021.154886
Abstract: BACKGROUND Pregnancy-associated plasma protein-A (PAPP-A) is an enzyme that increases IGF-activity through cleavage of IGF-binding proteins (IGFBPs), primarily IGFBP-4, whereby bound IGF-I becomes released as a free molecule. The enzymatic activity of PAPP-A is irreversibly… read more here.
Keywords: igfbp; gastric bypass; papp; changes igf ... See more keywords
Diagnostic Value of IGFBP-2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case-Control Study
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/5075569
Abstract: Purpose To identify novel biomarker insulin-like growth factor binding protein-2 (IGFBP-2) associated with preeclampsia (PE) before 20 weeks of gestation and to explore the predictive value of plasma IGFBP-2 in PE. Methods A prospective nested… read more here.
Keywords: preeclampsia weeks; prospective nested; igfbp; value ... See more keywords
Abstract 1095: Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) regulates mitochondrial dynamics, EMT and angiogenesis in progression of prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1095
Abstract: Prostate cancer (PCa) is a major epithelial cancer among men and with the second highest incidence rate, worldwide. The high ratio of IGF-1/IGFBP-3 correlates with increased risk of many cancers including prostate cancer. In present… read more here.
Keywords: igfbp; prostate cancer; du145; cancer ... See more keywords
Effects of gastric sleeve surgery on the serum levels of GH, IGF-1 and IGF-binding protein 2 in healthy obese patients
Sign Up to like & getrecommendations! Published in 2020 at "BMC Gastroenterology"
DOI: 10.1186/s12876-020-01309-9
Abstract: Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1… read more here.
Keywords: igfbp; gastric sleeve; surgery; igf igf ... See more keywords
Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Orthodontics"
DOI: 10.1186/s40510-017-0165-1
Abstract: BackgroundDetermination of skeletal maturation and remaining growth potential is an essential part of treatment planning in orthodontics. The aim of our study was to determine the relationship between IGF-1 levels, IGFBP-3 levels with CVM staging… read more here.
Keywords: igfbp; igf levels; stage; growth ... See more keywords
Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine journal"
DOI: 10.1507/endocrj.ej17-0156
Abstract: Insulin-like growth factor-binding protein (IGFBP)-5 is a secreted protein that binds to IGFs and modulates IGF actions, as well as regulates cell proliferation, migration, and apoptosis independent of IGF. Proper cellular localization is critical for… read more here.
Keywords: igfbp; importin; importin importin; igfbp nuclear ... See more keywords
IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of endocrinology"
DOI: 10.1530/eje-18-0422
Abstract: Objective Insulin-like growth factor-binding protein-2 (IGFBP-2) concentrations are low in subjects with metabolic syndrome and type 2 diabetes. Intriguingly, recent studies have demonstrated an association between high IGFBP-2 concentrations and increased mortality not only in… read more here.
Keywords: igfbp levels; insulin sensitivity; insulin; igfbp ... See more keywords
Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Molecular Hepatology"
DOI: 10.3350/cmh.2022.0019
Abstract: Background/Aims We aimed to define an optimal target population and drug-specific biomarkers that may predict dipeptidyl peptidase (DPP)-4 inhibitor responses in non-alcoholic fatty liver disease (NAFLD). Methods An exploration study (study I) was performed using… read more here.
Keywords: dipeptidyl peptidase; dpp inhibitor; inhibitor; basket ... See more keywords