Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03596-4
Abstract: IGFBP2 is one of the highly expressed genes in glioblastoma (GBM). It has both IGF dependent and independent activities. IGF independent actions are mediated by the activation of integrin signalling through its RGD motif present… read more here.
Keywords: nuclear catenin; regulation catenin; catenin; cytoplasmic catenin ... See more keywords
Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1719474115
Abstract: Significance Pulmonary alveolar type I (AT1) cells are essential for the gas-exchange function of lungs. AT1 cells retain their cellular plasticity during injury-induced alveolar regeneration. However, we know very little about the developmental heterogeneity of… read more here.
Keywords: at1 cell; at1 cells; at1; igfbp2 ... See more keywords
BS52 The effects of IGFBP2 over-expression on vascular function and smooth muscle
Sign Up to like & getrecommendations! Published in 2019 at "Heart"
DOI: 10.1136/heartjnl-2019-bcs.213
Abstract: Introduction Insulin-like growth factor binding protein 2 (IGFBP2) plays an important role in cell proliferation and migration in numerous cell types. However, little is known about the effects of IGFBP2 on vascular function. We have… read more here.
Keywords: expression; mice; figure; igfbp2 ... See more keywords
Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
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DOI: 10.3390/ijms22031133
Abstract: Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great… read more here.
Keywords: insulin; obesity; insulin resistance; igfbp2 ... See more keywords
IGFBP2 Drives Regulatory T Cell Differentiation through STAT3/IDO Signaling Pathway in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12122005
Abstract: Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies. Elevated regulatory T cell (Treg) infiltration has a potent immunosuppressive function in tumor biology, which contributes to low survival in PDAC. Nonetheless, the crosstalk between… read more here.
Keywords: igfbp2; microenvironment; regulatory cell; tumor ... See more keywords