circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR‐661/IGFBP5 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29055
Abstract: Increasing evidence demonstrates the crucial regulatory functions of circular RNAs in different cancer types. The major aim of the current study was to establish functions of circPIP5K1A during ovarian cancer. Our results showed an increased… read more here.
Keywords: mir 661; circpip5k1a; ovarian cancer; cancer progression ... See more keywords
Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29191
Abstract: It is previously suggested that insulin‐like growth factor binding proteins (IGFBPs) potentially share an association with disc degeneration (DD) that causes back pain. This study aimed at exploring the functional relevance of IGFBP5 in DD… read more here.
Keywords: erk mapk; proliferation; mapk axis; igfbp5 ... See more keywords
IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117997
Abstract: AIMS Non-alcoholic fatty liver disease (NAFLD) characterized by excessive hepatic fat deposition is an increasing public health issue worldwide. Insulin resistance is a pivotal factor in NAFLD progression. Studies have found that IGFBP5 was related… read more here.
Keywords: insulin; activating ampk; non alcoholic; igfbp5 ... See more keywords
IGFBP5 is Upregulated and Associated with Poor Prognosis in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s370576
Abstract: Purpose This study aimed to investigate the role of IGFBP5 in colorectal cancer (CRC) and the relationship between the expression of IGFBP5 and clinicopathological parameters in CRC patients. Patients and Methods Immunohistochemical analysis was used… read more here.
Keywords: expression igfbp5; crc; analysis; cancer ... See more keywords
Biological effects and regulation of IGFBP5 in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.983793
Abstract: The insulin-like growth factor receptor (IGF1R) pathway plays an important role in cancer progression. In breast cancer, the IGF1R pathway is linked to estrogen-dependent signaling. Regulation of IGF1R activity is complex and involves the actions… read more here.
Keywords: breast cancer; igfbp5; regulation; cancer ... See more keywords
Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution
Sign Up to like & getrecommendations! Published in 2023 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2023042
Abstract: Age-related thymic involution is one of the significant reasons for induced immunity decline. Recent evidence has indicated that lncRNAs are widely involved in regulating organ development. However, the lncRNA expression profiles in mouse thymic involution… read more here.
Keywords: lnc 5423; thymic involution; mouse thymic; involution ... See more keywords