In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing
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DOI: 10.1007/s10517-018-4060-7
Abstract: IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was… read more here.
Keywords: igfbp6 gene; gene; role; breast cancer ... See more keywords
Changes in the Metastatic Properties of MDA-MB-231 Cells after IGFBP6 Gene Knockdown Is Associated with Increased Expression of miRNA Genes Controlling INSR, IGF1R, and CCND1 Genes
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04409-z
Abstract: Metastatic cascade is associated with the process of epithelial-mesenchymal transition accompanied by changes in cell proliferation, migration, adhesion, and invasiveness mediated by the insulin-like growth factor (IGF) signal pathway. IGFBP6 protein binds IGF and prevents… read more here.
Keywords: igfbp6 gene; mda 231; gene knockdown; insr ... See more keywords