Insulin‐like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14120
Abstract: Insulin like growth factor binding protein 7 (IGFBP7) is a marker of senescence secretome and a novel biomarker in patients with heart failure (HF). We evaluated the prognostic value of IGFBP7 in patients with heart… read more here.
Keywords: heart failure; insulin like; like growth; igfbp7 ... See more keywords
IGFBP7 contributes to epithelial‐mesenchymal transition of HPAEpiC cells in response to radiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28516
Abstract: Radiation‐induced lung injury (RILI) frequently occurs in patients with thoracic malignancies. In response to radiation, alveolar epithelial cells (AEC) undergo epithelial‐mesenchymal transition (EMT) and contribute to the pathogenesis of RILI. Insulin‐like growth factor binding protein… read more here.
Keywords: mesenchymal transition; response radiation; hpaepic cells; igfbp7 ... See more keywords
Urinary [TIMP-2]•[IGFBP7], TIMP-2, IGFBP7, NGAL, and L-FABP for the prediction of acute kidney injury following cardiovascular surgery in Japanese patients
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-025-02671-2
Abstract: Acute kidney injury (AKI) following cardiac surgery is common and is associated with poor outcomes. The combination of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) is a strong… read more here.
Keywords: igfbp7 timp; timp igfbp7; stage; igfbp7 ... See more keywords
Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: A prospective cohort study.
Sign Up to like & getrecommendations! Published in 2021 at "Carcinogenesis"
DOI: 10.1093/carcin/bgab090
Abstract: The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. Host factors, including lifestyle, anthropometry, and metabolic profile, might influence tumor-specific IGFBP7. This study aimed to investigate whether IGFBP7… read more here.
Keywords: breast cancer; igfbp7; tumor specific; cancer ... See more keywords
Abstract 4936: The association between plasma IGFBP7 and cancer incidence, cancer mortality, and all-cause mortality in ARIC
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4936
Abstract: Insulin-like Growth Factor Binding Protein 7 (IGFBP7) may modulate IGF signaling and influence non-IGF molecular mechanisms. We analyzed whether IGFBP7 concentration in plasma is associated with risk of cancer incidence, cancer mortality, and all-cause mortality.… read more here.
Keywords: cancer; cause mortality; cancer incidence; mortality ... See more keywords
Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype
Sign Up to like & getrecommendations! Published in 2024 at "Neurology"
DOI: 10.1212/wnl.0000000000209696
Abstract: Background and Objectives The term “ALS Reversal” describes patients who initially meet diagnostic criteria for amyotrophic lateral sclerosis (ALS) or had clinical features most consistent with progressive muscular atrophy (PMA) but subsequently demonstrated substantial and… read more here.
Keywords: amyotrophic lateral; igfbp7; reversal phenotype; lateral sclerosis ... See more keywords
IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0501
Abstract: Insufficient trophoblast invasion at the maternal-fetal interface contributes to abortion-prone pregnancy. Cyclosporine A (CsA) can exert therapeutic effects on unexplained recurrent spontaneous abortion (URSA) by promoting trophoblast invasion. A previous study showed decreased expression of… read more here.
Keywords: abortion; trophoblast invasion; expression; igfbp7 ... See more keywords
Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018030265
Abstract: BACKGROUND Recent clinical data support the utility/superiority of a new AKI biomarker ("NephroCheck"), the arithmetic product of urinary TIMP × IGFBP7 concentrations. However, the pathophysiologic basis for its utility remains ill defined. METHODS To clarify… read more here.
Keywords: timp2 igfbp7; igfbp7; aki; urinary timp2 ... See more keywords
IGFBP7 and the Tumor Immune Landscape: A Novel Target for Immunotherapy in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.898493
Abstract: Insulin-like growth factor binding protein-7 (IGFBP7) was recently reported to be a ligand of CD93, a potential target to normalize vasculature and attenuate immunotherapy. However, its role in the tumor microenvironment (TME) and immunotherapy response… read more here.
Keywords: immunotherapy; igfbp7; bladder cancer; tumor ... See more keywords
Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery: A Prospective Cohort Study
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13061047
Abstract: Acute kidney injury (AKI) is common after pediatric cardiac surgery (CS). Several urine biomarkers have been validated to detect AKI earlier. The objective of this study was to evaluate urine CHI3L1, NGAL, TIMP-2, IGFBP7, and… read more here.
Keywords: aki; timp; chi3l1 ngal; igfbp7 ... See more keywords
Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.51546
Abstract: In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new… read more here.
Keywords: type rosetting; infected erythrocytes; plasmodium infected; igfbp7 ... See more keywords