On placental and lactational transfer of IgG‐based therapeutic proteins – Current understanding and knowledge gaps from a clinical pharmacology perspective
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Translational Science"
DOI: 10.1111/cts.70049
Abstract: Maternal medication use may expose the developing fetus through placental transfer or the infant through lactational transfer. Because pregnant and lactating individuals have been historically excluded from early drug development trials, there is often limited… read more here.
Keywords: pharmacology; igg based; transfer; based therapeutic ... See more keywords
A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003882
Abstract: Background In lymphoid malignancies, the introduction of chimeric antigen receptor T (CAR-T) cells and bispecific antibodies (bsAbs) has achieved remarkable clinical success. However, such immunotherapeutic strategies are not yet established for acute myeloid leukemia (AML),… read more here.
Keywords: aml; cln 049; novel igg; treatment ... See more keywords