Effects of purine-scaffold inhibitors on HUVECs: Involvement of the purinergic pathway and interference with ATP. Implications for preventing the adverse effects of extracellular Grp94
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100661
Abstract: Background Extracellular Glucose-regulated protein94 (Grp94) is linked to pathological conditions disrupting the obligatory intracellular location of this Heat Shock Protein (HSP). In plasma, Grp94 is linked to IgG in complexes that drive adverse effects on… read more here.
Keywords: grp94 igg; purine scaffold; scaffold inhibitors; grp94 ... See more keywords
Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis‐mediated bone loss
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DOI: 10.1111/sji.13009
Abstract: Immunoglobulin G (IgG) is important in clearance and recognition of previously presented antigens and after activation, IgGs can interact with the Fc gamma receptors (FcγRs) on haematopoietic cells, including bone‐resorbing osteoclasts. The pathogenicity of IgG,… read more here.
Keywords: arthritis mediated; bone loss; mediated bone; igg complexes ... See more keywords
IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.761816
Abstract: Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. Neutrophils express IgA… read more here.
Keywords: formation; net formation; igg complexes; iga igg ... See more keywords