Altered IgG glycosylation at COVID‐19 diagnosis predicts disease severity
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149491
Abstract: The nature of the immune responses associated with COVID‐19 pathogenesis and disease severity, as well as the breadth of vaccine coverage and duration of immunity, is still unclear. Given the unpredictability for developing a severe/complicated… read more here.
Keywords: diagnosis; igg glycosylation; severity; altered igg ... See more keywords
Three Major Gastrointestinal Cancers Could Be Distinguished through Subclass-Specific IgG Glycosylation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00572
Abstract: Esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC) are three major digestive tract tumors with higher morbidity and mortality due to significant molecular heterogeneity. Altered IgG glycosylation has been observed in inflammatory activities… read more here.
Keywords: igg glycosylation; specific igg; cancer; subclass specific ... See more keywords
IgG-Fc glycosylation before and after rituximab treatment in immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59651-7
Abstract: The interactions of antibodies with myeloid Fcγ receptors and the complement system are regulated by an Asn297-linked glycan in the Fc portion of IgG. Alterations of serum IgG-Fc glycosylation have been reported in various autoimmune… read more here.
Keywords: igg glycosylation; glycosylation; immune thrombocytopenia; rituximab treatment ... See more keywords
On enzymatic remodeling of IgG glycosylation; unique tools with broad applications
Sign Up to like & getrecommendations! Published in 2019 at "Glycobiology"
DOI: 10.1093/glycob/cwz085
Abstract: Abstract The importance of IgG glycosylation has been known for many years not only by scientists in glycobiology but also by human pathogens that have evolved specific enzymes to modify these glycans with fundamental impact… read more here.
Keywords: igg glycosylation; enzymatic remodeling; igg glycans; glycosylation ... See more keywords
IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age
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DOI: 10.3389/fimmu.2018.03166
Abstract: Preterm infants acquire reduced amounts of Immunoglobulin G (IgG) via trans-placental transfer as compared to term infants which might explain their high susceptibility for infections. The reduced amount of IgG antibodies also results in a… read more here.
Keywords: igg glycosylation; glycosylation patterns; preterm infants; patterns preterm ... See more keywords
Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.633214
Abstract: Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune… read more here.
Keywords: igg glycosylation; versus host; disease; host disease ... See more keywords
Cytokines in the Immune Microenvironment Change the Glycosylation of IgG by Regulating Intracellular Glycosyltransferases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.724379
Abstract: Background Changes in IgG glycosylation, as a novel pathological feature, are observed in various autoimmune diseases (AIDs). The glycosylation patterns of IgG play a critical role in regulating the biological function and stability of IgG… read more here.
Keywords: igg; igg glycosylation; intracellular glycosyltransferases; glycosylation ... See more keywords
Identification and validation of IgG N-glycosylation biomarkers of esophageal carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.981861
Abstract: Introduction Altered Immunoglobulin G (IgG) N-glycosylation is associated with aging, inflammation, and diseases status, while its effect on esophageal squamous cell carcinoma (ESCC) remains unknown. As far as we know, this is the first study… read more here.
Keywords: glycan score; igg glycosylation; 001 001; population ... See more keywords
Coronavirus Disease 2019-Related Alterations of Total and Anti-Spike IgG Glycosylation in Relation to Age and Anti-Spike IgG Titer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.775186
Abstract: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been affecting the world since January 2020 and has caused millions of deaths. To gain a better insight into molecular… read more here.
Keywords: igg glycosylation; disease; spike igg; anti spike ... See more keywords
The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto’s Thyroiditis: An in Vitro Model of Thyroid Autoimmunity
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10020171
Abstract: Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in destruction of thyroid tissue in Hashimoto’s thyroiditis (HT). N-glycosylation of the Fc fragment affects the effector functions of IgG by enhancing or suppressing the… read more here.
Keywords: igg glycosylation; adcc; cytotoxicity; cell ... See more keywords
Retrospective screening of serum IgG glycosylation biomarker for primary Sjögren’s syndrome using lectin microarray
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DOI: 10.7717/peerj.14853
Abstract: Background Primary Sjögren’s syndrome (PSS) is a systemic autoimmune disease resulting in significant loss of systemic gland secretory function. IgG glycosylation abnormalities had been found to play important roles in autoimmune diseases. Here, we aim… read more here.
Keywords: serum igg; lectin microarray; igg glycosylation; glycosylation ... See more keywords