Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy
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DOI: 10.1186/s12882-017-0722-3
Abstract: BackgroundAccumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have been identified as major components in cIgA1. Before, Gd-IgA1 was reported… read more here.
Keywords: specific igg; igg; iga1; mesangial cells ... See more keywords
Sialylation of IgG inhibits the formation of galactose-deficient IgA1-containing immune complexes and protects mesangial cells from injury in IgA nephropathy
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DOI: 10.1186/s12882-021-02657-8
Abstract: Background The addition of sialic acid alters IgG from a pro-inflammatory state to an anti-inflammatory state. However, there is a lack of research on the changes of IgG sialylation in IgA nephropathy (IgAN). Methods This… read more here.
Keywords: igg; igg iga1; iga1; mesangial cells ... See more keywords