Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
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DOI: 10.1080/19420862.2020.1812210
Abstract: ABSTRACT Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning… read more here.
Keywords: characterization vhh; trispecific antibody; igg like; like trispecific ... See more keywords
Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies
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DOI: 10.1080/19420862.2021.1981806
Abstract: ABSTRACT Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulfide bonds are common… read more here.
Keywords: ch2; sds; shoulder peak; igg like ... See more keywords
A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties
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DOI: 10.1080/19420862.2022.2044435
Abstract: ABSTRACT Targeting PD1/PDL1 with blocking antibodies for cancer therapy has shown promising benefits in the clinic, but only approximately 20–30% of patients develop durable clinical responses to the treatment. Bispecific antibodies (BsAbs) that combine PD1/PDL1… read more here.
Keywords: igg like; immune checkpoint; desired igg; anti pd1 ... See more keywords
Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy
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DOI: 10.1155/2019/4516041
Abstract: Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising… read more here.
Keywords: immunoglobulin gamma; igg like; antibody; tumor therapy ... See more keywords