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   Articles with "igg like" as a keyword



General strategies for IgG‐like bispecific antibody purification

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recommendations! Published in 2024 at "Biotechnology Progress"

DOI: 10.1002/btpr.3515

Abstract: Bispecific antibodies (bsAbs) can simultaneously bind two different antigens or epitopes. Their dual‐targeting capability enables novel mechanisms of action, gaining therapeutic advantages over conventional monospecific mAbs. In recent years, the number of bsAbs grows rapidly… read more here.

Keywords: general strategies; bispecific antibody; igg like; like bispecific ... See more keywords

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

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recommendations! Published in 2020 at "mAbs"

DOI: 10.1080/19420862.2020.1812210

Abstract: ABSTRACT Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning… read more here.

Keywords: characterization vhh; trispecific antibody; igg like; like trispecific ... See more keywords

Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies

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recommendations! Published in 2021 at "mAbs"

DOI: 10.1080/19420862.2021.1981806

Abstract: ABSTRACT Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulfide bonds are common… read more here.

Keywords: ch2; sds; shoulder peak; igg like ... See more keywords

A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties

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recommendations! Published in 2022 at "mAbs"

DOI: 10.1080/19420862.2022.2044435

Abstract: ABSTRACT Targeting PD1/PDL1 with blocking antibodies for cancer therapy has shown promising benefits in the clinic, but only approximately 20–30% of patients develop durable clinical responses to the treatment. Bispecific antibodies (BsAbs) that combine PD1/PDL1… read more here.

Keywords: igg like; immune checkpoint; desired igg; anti pd1 ... See more keywords

Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy

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recommendations! Published in 2019 at "Journal of Immunology Research"

DOI: 10.1155/2019/4516041

Abstract: Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising… read more here.

Keywords: immunoglobulin gamma; igg like; antibody; tumor therapy ... See more keywords