Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-021-00993-w
Abstract: Purpose The human antibody repertoire forms in response to infections, the microbiome, vaccinations, and environmental exposures. The specificity of such antibody responses was compared among a cohort of toddlers to identify differences between seropositive versus… read more here.
Keywords: toddlers reveals; igg responses; antibody; igg profiling ... See more keywords
Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Advanced Research"
DOI: 10.1016/j.jare.2021.11.014
Abstract: Introduction The COVID-19 global pandemic is far from ending. There is an urgent need to identify applicable biomarkers for early predicting the outcome of COVID-19. Growing evidences have revealed that SARS-CoV-2 specific antibodies evolved with… read more here.
Keywords: non structural; sars cov; outcome covid; igg responses ... See more keywords
SARS-CoV-2 outbreak in a synagogue community: longevity and strength of anti-SARS-CoV-2 IgG responses
Sign Up to like & getrecommendations! Published in 2021 at "Epidemiology and Infection"
DOI: 10.1017/s0950268821001369
Abstract: Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic is still ongoing along with the global vaccination efforts against it. Here, we aimed to understand the longevity and strength of anti-SARS-CoV-2 IgG responses in a small community… read more here.
Keywords: anti sars; cov igg; strength anti; sars cov ... See more keywords
Modular Polymer Antigens to Optimize Immunity.
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DOI: 10.1021/acs.biomac.9b01049
Abstract: Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal… read more here.
Keywords: igg responses; polymer antigens; modular polymer; cell ... See more keywords
HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
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DOI: 10.1038/s41467-019-08739-4
Abstract: The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver immunizations to the sublingual and buccal (SL/B) tissue… read more here.
Keywords: needle free; vaccination; igg responses; mucosal immunity ... See more keywords
A functional spleen contributes to afucosylated IgG in humans
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DOI: 10.1038/s41598-021-03196-w
Abstract: As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate antigen-specific immune responses. In particular, the splenic microenvironment has been… read more here.
Keywords: spleen contributes; functional spleen; igg responses; role ... See more keywords
P0115 Selective immune responses to Lachnospiraceae flagellins discriminate therapy-naive pediatric Crohn’s disease patients with distinct host-microbial interaction
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0289
Abstract: Pathogenic CD4+ T-cell responses to commensal microbial antigens drive intestinal inflammation in Crohn’s disease (CD). Both hypo- or hyperactive anti-microbial innate immunity could underlie these aberrant T-cell responses. CD patients have increased IgG and T… read more here.
Keywords: igg; therapy naive; responses lachnospiraceae; cell ... See more keywords
Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.1101/2024.09.24.614082
Abstract: Malaria remains a significant burden, and a fully protective vaccine against Plasmodium falciparum is critical for reducing morbidity and mortality. Antibody responses against the blood-stage antigen merozoite surface protein 2 (MSP2) are associated with protection… read more here.
Keywords: conserved termini; protein; igg responses; naturally acquired ... See more keywords
Antigen (Ag) spread after sipuleucel-T and correlation with overall survival (OS): A real-world experience.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16504
Abstract: e16504 Background: Sipuleucel-T is an autologous cellular immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer. In IMPACT (NCT00065442), a phase 3 trial, sipuleucel-T-induced immune responses against target Ag prostatic acid phosphatase (PAP) or… read more here.
Keywords: sipuleucel; spread; responses secondary; real world ... See more keywords
Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern
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DOI: 10.1371/journal.pone.0249936
Abstract: Detection of antibody reactivity to appropriate, specific parasite antigens may constitute a sensitive and cost-effective alternative to current tools to monitor malaria transmission across different endemicity settings. This study aimed to determine the suitability of… read more here.
Keywords: intensity pattern; transmission; transmission intensity; igg responses ... See more keywords
Human IgG responses to Aedes mosquito salivary peptide Nterm-34kDa and its comparison to Anopheles salivary antigen (gSG6-P1) IgG responses measured among individuals living in Lower Moshi, Tanzania
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DOI: 10.1371/journal.pone.0276437
Abstract: Background The level of human exposure to arbovirus vectors, the Aedes mosquitoes, is mainly assessed by entomological methods which are labour intensive, difficult to sustain at a large scale and are affected if transmission and… read more here.
Keywords: seroprevalence; nterm 34kda; season; igg responses ... See more keywords