Validation and cross-reactivity pattern assessment of monoclonal antibodies used for the screening of donor-specific IgG antibody subclasses in transplant recipients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2020.112847
Abstract: The screening for IgG subclass donor-specific antibodies (DSAs) in allograft recipients uses IgG1-4 subclass-specific monoclonal antibodies (mAbs) that should be mono-specific. The cross-reactivity discrepancies reported for IgG subclass-specific mAbs warranted a critical cross-reactivity pattern analysis… read more here.
Keywords: subclass specific; igg subclass; subclass; cross reactivity ... See more keywords
Comparative analysis of influenza A(H3N2) virus hemagglutinin specific IgG subclass and IgA responses in children and adults after influenza vaccination.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.10.024
Abstract: Two different influenza vaccines are generally used in many countries; trivalent live attenuated influenza vaccine (LAIV3) and trivalent inactivated influenza vaccine (IIV3). Studies comparing the antibody response to IIV3 and LAIV3 commonly investigate the seroprotective… read more here.
Keywords: igg subclass; comparative analysis; subclass iga; hemagglutinin specific ... See more keywords
Impact of IgG subclass on molecular properties of monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1993768
Abstract: Immunoglobulin G-based monoclonal antibodies (mAbs) have become a dominant class of biotherapeutics in recent decades. Approved antibodies are mainly of the subclasses IgG1, IgG2, and IgG4, as well as their derivatives. Over the decades, the… read more here.
Keywords: igg subclass; impact igg; monoclonal antibodies; molecular properties ... See more keywords
Impact of IgG subclass on monoclonal antibody developability
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2191302
Abstract: ABSTRACT IgG-based monoclonal antibody therapeutics, which are mainly IgG1, IgG2, and IgG4 subclasses or related variants, have dominated the biotherapeutics field for decades. Multiple laboratories have reported that the IgG subclasses possess different molecular characteristics… read more here.
Keywords: impact igg; igg subclass; monoclonal antibody; subclass ... See more keywords
Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001716
Abstract: Objective: Given the emerging appreciation for the role of antibody-dependent effector functions and IgG subclass distribution among spontaneous controllers of HIV, we sought to determine whether antibody-associated features diverged in early HIV infection between patients… read more here.
Keywords: igg subclass; hiv; infection; antibody ... See more keywords
The Biology of IgG Subclasses and Their Clinical Relevance to Transplantation.
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DOI: 10.1097/tp.0000000000001816
Abstract: Immunoglobulin G (IgG) is the dominant immunoglobulin and can be divided into 4 distinct subclasses. The evolution of IgG subclass switches is regulated by interaction with T cells and follows a 1-way direction (IgG3 →… read more here.
Keywords: igg subclass; transplantation; biology; igg subclasses ... See more keywords
The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers' Pneumoconiosis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/9233386
Abstract: Evidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers' pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic… read more here.
Keywords: workers pneumoconiosis; igg subclass; coal; coal workers ... See more keywords
Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.121.262383
Abstract: Visual Abstract Immuno-PET is a powerful tool to noninvasively characterize the in vivo biodistribution of engineered antibodies. Methods: L1 cell adhesion molecule–targeting humanized (HuE71) IgG1 and IgG4 antibodies bearing identical variable heavy- and light-chain sequences… read more here.
Keywords: biodistribution; influence modifications; hue71 igg1; igg subclass ... See more keywords
Definition of IgG Subclass-Specific Glycopatterns in Idiopathic Membranous Nephropathy: Aberrant IgG Glycoforms in Blood
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094664
Abstract: The podocyte injury, and consequent proteinuria, that characterize the pathology of idiopathic membranous nephropathy (IMN) is mediated by an autoimmune reaction against podocyte antigens. In particular, the activation of pathways leading to abundant renal deposits… read more here.
Keywords: idiopathic membranous; igg subclass; subclass specific; membranous nephropathy ... See more keywords