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Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28254
Abstract: In the manufacture of therapeutic monoclonal antibodies, the clarified cell culture fluid (CCF) is typically loaded onto an initial protein A affinity capture column. Imperfect mass transfer and loading to maximum capacity can risk antibody…
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Keywords:
igg using;
continuous monitoring;
column;
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