Atomistic Modeling of Scattering Curves for Human IgG1/4 Reveals New Structure-Function Insights
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.10.024
Abstract: Small angle x-ray and neutron scattering are techniques that give solution structures for large macromolecules. The creation of physically realistic atomistic models from known high-resolution structures to determine joint x-ray and neutron scattering best-fit structures… read more here.
Keywords: ray neutron; igg1; fit; best fit ... See more keywords
Minimal physiologically‐based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti‐VEGF humanized IgG1 antibody in cynomolgus monkey
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.09.015
Abstract: &NA; In this study, we developed a first minimal physiologically‐based pharmacokinetic (mPBPK) model to investigate the complex interaction effects of endocytosis rate/FcRn binding affinity at both acidic/physiological pH on the pharmacokinetics (PK) of the anti‐VEGF… read more here.
Keywords: anti vegf; igg1; model; fcrn ... See more keywords
Influence of glycan modification on IgG1 biochemical and biophysical properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.12.061
Abstract: Graphical abstract Figure. No caption available. HighlightsGlycosylation affects both physico‐chemical properties of mAbs and their interactions with the key receptors.Fully deglycosylated, hypergalactosylated and hypersialylated mAb molecules were produced and characterized.Aggregation propensity is not increased for… read more here.
Keywords: igg1; influence glycan; ggr; hypergalactosylated hypersialylated ... See more keywords
Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Research"
DOI: 10.1038/s41390-020-01271-y
Abstract: Potentially, orally administered antibodies specific to enteric pathogens could be administered to infants to prevent diarrheal infections, particularly in developing countries where diarrhea is a major problem. However, to prevent infection, such antibodies would need… read more here.
Keywords: gastrointestinal tract; igg1; antibody; digestion ... See more keywords
IgG1 variant promotes autoimmunity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-018-0127-0
Abstract: A newly discovered variant of immunoglobulin G1 (IgG1) that can modulate B cell activation and differentiation is also a risk variant for systemic lupus erythematosus (SLE), according to a new study published in Science. These… read more here.
Keywords: igg; igg1; sle; variant ... See more keywords
Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13845-8
Abstract: Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fucosylation of IgG1-Fc N-glycans negatively… read more here.
Keywords: igg1; core fucosylation; fucosylation; riiia ... See more keywords
Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain
Sign Up to like & getrecommendations! Published in 2017 at "mAbs"
DOI: 10.1080/19420862.2016.1277301
Abstract: ABSTRACT We developed an IgG1 domain-tethering approach to guide the correct assembly of 2 light and 2 heavy chains, derived from 2 different antibodies, to form bispecific monovalent antibodies in IgG1 format. We show here… read more here.
Keywords: bispecific monovalent; igg1; formation; monovalent ... See more keywords
Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1991256
Abstract: ABSTRACT Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work focuses… read more here.
Keywords: chain; viscosity; igg1; heavy chain ... See more keywords
Murine Cross-Reactive Nonneutralizing Polyclonal IgG1 Antibodies Induced by Influenza Vaccine Inhibit the Cross-Protective Effect of IgG2 against Heterologous Virus in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00323-20
Abstract: Current influenza vaccines are generally effective against highly similar virus strains by inducing neutralizing antibodies. However, these antibodies fail to neutralize antigenically mismatched (heterologous) strains and therefore provide limited protection against them. Efforts are being… read more here.
Keywords: protection; cross reactive; igg1; cross ... See more keywords
Abstract LB-089: Targeting transferrin receptor 1 (TfR1) with the ch128.1/IgG1 antibody inhibits Epstein-Barr virus (EBV) driven lymphoproliferative growth and lymphomagenesis in immunosuppressed mice bearing human B cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-lb-089
Abstract: Epstein-Barr virus (EBV) is a human herpesvirus that is associated with malignancies of both B lymphocyte and epithelial cell origin. EBV is associated with the development of approximately 1.5% of all cancers worldwide, including AIDS-related… read more here.
Keywords: igg1; antibody; ebv driven; ch128 igg1 ... See more keywords
IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140925
Abstract: While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition, emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based correlates of reduced risk of protection. While… read more here.
Keywords: igg1; iga; igg3; rv144 ... See more keywords