Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies.
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DOI: 10.1007/s11095-021-03089-7
Abstract: PURPOSE To evaluate the physical and chemical degradation of monoclonal antibodies in the presence of Zn2+. METHODS A full length IgG1 monoclonal antibody (mAb1) was formulated with various amounts of Zn2+. The resulting mixture was… read more here.
Keywords: aggregation; presence; monoclonal antibodies; mediated aggregation ... See more keywords
Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies
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DOI: 10.1021/acs.analchem.9b05385
Abstract: The use of NMR spectroscopy has emerged as a premier tool to characterize the higher order structure of protein therapeutics and in particular IgG1 monoclonal antibodies (mAbs). Due to their large ... read more here.
Keywords: igg1 monoclonal; higher order; order structure; monoclonal antibodies ... See more keywords
Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties
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DOI: 10.1080/19420862.2016.1270492
Abstract: ABSTRACT By simultaneous binding two disease mediators, bispecific antibodies offer the opportunity to broaden the utility of antibody-based therapies. Herein, we describe the design and characterization of Bs4Ab, an innovative and generic bispecific tetravalent antibody… read more here.
Keywords: full length; bs4ab; antibody; igg1 monoclonal ... See more keywords
Preferential interactions of trehalose, L-arginine.HCl and sodium chloride with therapeutically relevant IgG1 monoclonal antibodies
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DOI: 10.1080/19420862.2017.1358328
Abstract: ABSTRACT Preferential interactions of weakly interacting formulation excipients govern their effect on the equilibrium and kinetics of several reactions of protein molecules in solution. Using vapor pressure osmometry, we characterized the preferential interactions of commonly… read more here.
Keywords: monoclonal antibodies; arginine hcl; preferential interactions; igg1 monoclonal ... See more keywords