IgG3 regulates tissue-like memory B cells in HIV-infected individuals
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0180-5
Abstract: Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system–activating effects of… read more here.
Keywords: igg3; tissue like; like memory; hiv infected ... See more keywords
Highly active engineered IgG3 antibodies against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107249118
Abstract: Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed at an unprecedented speed. Notwithstanding, there is a vague understanding of the various Ab functions induced beyond antigen binding by the heavy-chain constant domain. To… read more here.
Keywords: active engineered; igg3; igg3 antibodies; engineered igg3 ... See more keywords
Reply to Pandey: Possible functional impact of IgG3 allotype constant region
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120537119
Abstract: In a letter to the editor (1), Janardan Pandey comments on our recent study demonstrating that IgG3 switch variants of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibody (Ab) are superior to other… read more here.
Keywords: pandey; activity; igg; igg3 ... See more keywords
Consideration of C1q and FcRn binding to allotypically disparate IgG3 could aid in engineering more efficacious anti-SARS-CoV-2 mAbs
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2306078120
Abstract: Izadi et al. (1) have added to the increasing body of evidence that IgG3 monoclonal antibodies (mAbs) are more potent than their IgG1 counterparts in mediating Fc-mediated effector functions. They also show that immunoglobulin constant… read more here.
Keywords: fcrn binding; immunology; half life; fcrn ... See more keywords
IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140925
Abstract: While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition, emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based correlates of reduced risk of protection. While… read more here.
Keywords: igg1; iga; igg3; rv144 ... See more keywords
Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1462-z
Abstract: BackgroundAutoantibodies against the paranodal protein contactin-1 have recently been described in patients with severe acute-onset autoimmune neuropathies and mainly belong to the IgG4 subclass that does not activate complement. IgG3 anti-contactin-1 autoantibodies are rare, but… read more here.
Keywords: anti contactin; igg; igg3; disease ... See more keywords
IgG cryoglobulinemia.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201809_15943
Abstract: OBJECTIVE Mixed Cryoglobulinemia is the most well-known Hepatitis C Virus (HCV)-associated extrahepatic manifestation. MC is both an autoimmune and B-lymphoproliferative disorder. Cryoglobulins (CGs) are classified into three groups according to immunoglobulin (Ig) composition: type I… read more here.
Keywords: cryoglobulinemia; igg cryoglobulinemia; igg3; type ... See more keywords
Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.950909
Abstract: A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for treatment and to accelerate malaria elimination efforts. To address this challenge, our laboratory has developed an eight-antigen panel that detects total IgG… read more here.
Keywords: transmission intensity; vivax; transmission; moderate high ... See more keywords