Postoperative outcomes of biopsy versus debulking surgery for immunoglobulin G4-related ophthalmic disease: a retrospective comparative study
Sign Up to like & getrecommendations! Published in 2025 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-024-01157-0
Abstract: To compare the postoperative outcomes of corticosteroid therapy following biopsy with those following debulking surgery in patients with immunoglobulin G4 (IgG4)-related ophthalmic disease (IgG4-ROD). Retrospective comparative study. Fifteen patients diagnosed with IgG4-ROD (5 unilateral, 10… read more here.
Keywords: ophthalmic disease; group; related ophthalmic; debulking surgery ... See more keywords
Immunoglobulin G4–related lacrimal sac dacryocystocele: A novel case report
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2020.100789
Abstract: Purpose Immunoglobulin G4-related disease is a systemic fibroinflammatory disease of unknown etiology. Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) can manifest in multiple ways, but lacrimal sac involvement is rare. We present the first case in Chinese… read more here.
Keywords: immunoglobulin related; igg4 rod; lacrimal sac; case ... See more keywords
Discriminating between IgG4-related orbital disease and other causes of orbital inflammation with intra voxel incoherent motion (IVIM) MR imaging at 3T.
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic and interventional imaging"
DOI: 10.1016/j.diii.2021.06.006
Abstract: PURPOSE The purpose of this prospective study was to determine the capabilities of intravoxel incoherent motion (IVIM) MRI at 3 Tesla in discriminating between IgG4-related orbital disease (IgG4-ROD) and other causes of orbital inflammation. MATERIALS… read more here.
Keywords: igg4; igg4 rod; orbital inflammation; causes orbital ... See more keywords
Clinical analysis of ocular adnexal mucosa-associated lymphoid tissue lymphoma with IgG4-related ophthalmic disease.
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DOI: 10.1080/01676830.2021.1962365
Abstract: PURPOSE To analyse the incidence and characteristics of ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) with immunoglobulin G4 (IgG4)-related ophthalmic disease (IgG4-ROD), and to compare with IgG4-negative OAML. METHODS We enrolled 130 patients with pathology-confirmed… read more here.
Keywords: igg4; igg4 rod; disease; igg4 positive ... See more keywords
IgG4-related Ophthalmic Disease in Idiopathic Sclerosing and Non-Sclerosing Orbital Inflammation: A 25-Year Experience
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DOI: 10.1080/02713683.2019.1627462
Abstract: ABSTRACT Purpose: To determine the prevalence, clinical manifestations, and treatment outcomes of IgG4-related ophthalmic disease (IgG4-ROD) in previously diagnosed idiopathic orbital inflammation (IOI). Materials and Methods: Thirty one surgically treated patients with IOI between 1990… read more here.
Keywords: ophthalmic disease; igg4; igg4 rod; related ophthalmic ... See more keywords
The Role of Symptom Duration and Serologic Factors in the Relapse of IgG4-Related Ophthalmic Disease following Surgery: A Retrospective Cohort Study
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DOI: 10.1155/2022/5651506
Abstract: IgG4-related disease (IgG4-RD) affects multiple organs and is characterized by immune-mediated inflammation and fibrosis; IgG-RD affecting orbital tissue is known as IgG4-related ophthalmic disease (IgG4-ROD). This research is aimed at exploring whether symptom duration and… read more here.
Keywords: igg4 related; disease; igg4 rod; relapse ... See more keywords
Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/2742839
Abstract: Objective This study is aimed at discussing the value of RNA interference technology on inhibiting lacrimal gland fibrosis in IgG4-related ocular disease (IgG4-ROD). Methods Six patients with IgG4-ROD who came to the hospital for surgical… read more here.
Keywords: igg4 rod; lacrimal gland; apoptosis; proliferation ... See more keywords
Similarities and differences of a proliferation-inducing ligand expression in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases and mucosa-associated lymphoid tissue lymphoma
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DOI: 10.3389/fimmu.2025.1514003
Abstract: Objective This study aimed to investigate the expression condition of a proliferation-inducing ligand (APRIL) in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases (IgG4-ROD) and mucosa-associated lymphoid tissue (MALT) lymphoma. Patients and methods Fifteen… read more here.
Keywords: gland lesions; patients igg4; lacrimal gland; malt lymphoma ... See more keywords
Case Report: IgG4-related ophthalmic disease presenting with unilateral proptosis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1652730
Abstract: IgG4-related eye disease (IgG4-ROD) is characterized by diffuse swelling or well-defined masses in the lacrimal glands, extraocular muscles, and eyelids, often accompanied by eyelid swelling, proptosis, and diplopia. It typically affects both sides symmetrically and… read more here.
Keywords: igg4; disease; igg4 related; proptosis ... See more keywords
Activation of Mast-Cell-Derived Chymase in the Lacrimal Glands of Patients with IgG4-Related Ophthalmic Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052556
Abstract: The purpose of this present study was to investigate the distribution and expression of chymase in the lacrimal glands (LGs) of patients afflicted with IgG4-related ophthalmic disease (IgG4-ROD). LGs from patients with severe canalicular obstruction… read more here.
Keywords: chymase lacrimal; igg4 rod; lgs; chymase ... See more keywords
Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis
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DOI: 10.3390/life12101660
Abstract: Non-specific orbital inflammation (NSOI) and IgG4-related orbital disease (IgG4-ROD) are currently treated with non-specific immunosuppressive agents based on non-randomized, uncontrolled studies. Therefore, relapses and prolongated courses are common and remain challenging. For a more specific… read more here.
Keywords: lymphoma; igg4 rod; pathophysiology; progression orbital ... See more keywords