Abstract 1485: Allelic specificity of immunoglobulin heavy chain (IGH) translocation in B-cell acute lymphoblastic leukemia (B-ALL) unveiled by long-read sequencing
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DOI: 10.1158/1538-7445.am2018-1485
Abstract: Translocation that juxtaposes the IGH@ enhancer (Eμ) to a proto-oncogene such as CRLF2, EPOR and DUX4 is a common oncogenic mechanism that drives B-ALL. B-cells achieve immunoglobulin monospecificity by inactivating one of the IGH alleles… read more here.
Keywords: seq; dux4; long read; translocation ... See more keywords