High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
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DOI: 10.1182/bloodadvances.2021006659
Abstract: Key Points High surface IgM expression associates with shorter time to new treatment following ibrutinib therapy. Cells with high surface IgM expression retain residual signaling capacity downstream of BTK during ibrutinib therapy. read more here.
Keywords: surface igm; ibrutinib; high surface; levels associate ... See more keywords
Elevated IgM levels as a marker for a unique phenotype in patients with Ataxia telangiectasia
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DOI: 10.1186/s12887-018-1156-1
Abstract: BackgroundAtaxia telangiectasia (AT) is a rare, multi-systemic, genetic disorder. Mutations in the ATM gene cause dysfunction in cell-cycle, apoptosis and V (D) J recombination leading to neurodegeneration, cellular, humoral immunodeficiencies and predisposition to malignancies. Previous… read more here.
Keywords: phenotype; levels marker; igm levels; group ... See more keywords
Cerebrospinal Fluid IgM Levels in Association With Inflammatory Pathways in Multiple Sclerosis Patients
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DOI: 10.3389/fncel.2020.569827
Abstract: Background Intrathecal immunoglobulin M (IgM) synthesis has been demonstrated in the early disease stages of multiple sclerosis (MS) as a predictor factor of a worsening disease course. Similarly, increased cerebrospinal fluid (CSF) molecules related to… read more here.
Keywords: igm levels; csf; igm; multiple sclerosis ... See more keywords