Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia
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DOI: 10.1111/bjh.18502
Abstract: Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the… read more here.
Keywords: myd88; igm mgus; swm; cxcr4 ... See more keywords
Natural History of Asymptomatic IgM Monoclonal Gammopathies: Impact of the Bone Marrow Aspiration into the Classification and Prognosis
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DOI: 10.1182/blood-2018-99-115038
Abstract: Introduction: As in multiple myeloma, Waldenström macroglobulinemia (WM) is preceded by an asymptomatic phase, mainly as monoclonal gammopathy of undetermined significance (MGUS) or by a smoldering WM (SWM) phase. It has recently been reported that… read more here.
Keywords: igm monoclonal; igm mgus; swm; progression ... See more keywords
Advances in the understanding of IgM monoclonal gammopathy of undetermined significance
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DOI: 10.12688/f1000research.12880.1
Abstract: Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenström… read more here.
Keywords: advances understanding; igm mgus; undetermined significance; understanding igm ... See more keywords
Identification of a Candidate Gene Set Signature for the Risk of Progression in IgM MGUS to Smoldering/Symptomatic Waldenström Macroglobulinemia (WM) by a Comparative Transcriptome Analysis of B Cells and Plasma Cells
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DOI: 10.3390/cancers13081837
Abstract: Simple Summary IgM monoclonal gammopathy of undetermined significance (IgM MGUS) is an early precursor stage of the rare lymphoma Waldenström Macroglobulinemia (WM). Although comparative gene expression studies on WM, IgM MGUS, and normal B-cells (CTRLs)… read more here.
Keywords: igm; gene; igm mgus; waldenstr macroglobulinemia ... See more keywords
Nucleic Acid Biomarkers in Waldenström Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance
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DOI: 10.3390/diagnostics12040969
Abstract: Waldenström Macroglobulinemia (WM) is an indolent lymphoplasmacytic lymphoma, characterized by the production of excess immunoglobulin M monoclonal protein. WM belongs to the spectrum of IgM gammopathies, ranging from asymptomatic IgM monoclonal gammopathy of undetermined significance… read more here.
Keywords: igm; waldenstr macroglobulinemia; igm mgus; nucleic acid ... See more keywords