Unraveling the heterogeneity of IgM monoclonal gammopathies: a gene mutational and gene expression study
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DOI: 10.1007/s00277-017-3207-3
Abstract: Immunoglobulin M (IgM) monoclonal gammopathies show considerable variability, involving three different stages of presentation: IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), asymptomatic Waldenström’s macroglobulinemia (AWM), and symptomatic WM (SWM). Despite recent findings about the genomic… read more here.
Keywords: monoclonal gammopathies; igm monoclonal; gene expression; study ... See more keywords
Human IgM monoclonal antibodies block HIV-transmission to immune cells in cervico-vaginal tissues and across polarized epithelial cells in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28242-y
Abstract: The importance of natural IgM antibodies in protection against infections is still emerging and these antibodies have a potential role in the maintenance of homeostasis through clearance of apoptotic bodies, complement-dependent mechanisms, inflammation and exclusion… read more here.
Keywords: monoclonal antibodies; hiv; igm monoclonal; igm ... See more keywords
Natural History of Asymptomatic IgM Monoclonal Gammopathies: Impact of the Bone Marrow Aspiration into the Classification and Prognosis
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DOI: 10.1182/blood-2018-99-115038
Abstract: Introduction: As in multiple myeloma, Waldenström macroglobulinemia (WM) is preceded by an asymptomatic phase, mainly as monoclonal gammopathy of undetermined significance (MGUS) or by a smoldering WM (SWM) phase. It has recently been reported that… read more here.
Keywords: igm monoclonal; igm mgus; swm; progression ... See more keywords
IgM monoclonal gammopathies of clinical significance: diagnosis and management
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DOI: 10.3324/haematol.2022.280953
Abstract: IgM monoclonal gammopathy of undetermined significance is a pre-malignant condition for Waldenström macroglobulinemia and other B-cell malignancies, defined by asymptomatic circulating IgM monoclonal protein below 30 g/L with a lymphoplasmacytic bone marrow infiltration of less… read more here.
Keywords: clinical significance; igm monoclonal; significance; monoclonal gammopathy ... See more keywords
IgM monoclonal gammopathy of undetermined significance: clinicopathologic features with and without IgM-related disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282389
Abstract: A subset of patients with IgM monoclonal gammopathy of undetermined significance (MGUS) develop IgM-related disorders (IgM-RD) including peripheral neuropathy, cryoglobulinemia and/or cold agglutinin disease (CAD). We examined the clinical and bone marrow pathologic findings in… read more here.
Keywords: gammopathy undetermined; igm; igm monoclonal; undetermined significance ... See more keywords