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   Articles with "iguratimod" as a keyword



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Relative efficacy and safety of iguratimod monotherapy for the treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis

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recommendations! Published in 2020 at "Clinical Rheumatology"

DOI: 10.1007/s10067-020-04986-9

Abstract: Objectives This study aims to compare the efficacy and the safety of the iguratimod with placebo and other disease-modifying antirheumatic drugs (DMARDs) in adults with rheumatoid arthritis. Methods Two authors independently searched and selected randomized… read more here.

Keywords: iguratimod may; efficacy safety; iguratimod; rheumatology ... See more keywords
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Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways.

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recommendations! Published in 2020 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2020.107219

Abstract: BACKGROUND Iguratimod, a small molecular drug, has been proven to have effective bone protection for treatment of patients with bone loss-related diseases, such as rheumatoid arthritis (RA). However, the exact bone protective mechanism of iguratimod… read more here.

Keywords: bone; rankl tnf; bone loss; iguratimod ... See more keywords
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Iguratimod ameliorates nephritis by modulating the Th17/Treg paradigm in pristane-induced lupus.

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recommendations! Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.107563

Abstract: OBJECTIVE Iguratimod, an anti-rheumatic drug, has been widely used in the treatment of rheumatoid arthritis, but is still at an investigative stage for treatment of systemic lupus erythematosus (SLE). We examined the therapeutic effects of… read more here.

Keywords: th17 treg; pristane induced; induced lupus; iguratimod ... See more keywords
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Iguratimod alleviates tubulo-interstitial injury in mice with lupus

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recommendations! Published in 2022 at "Renal Failure"

DOI: 10.1080/0886022x.2022.2058962

Abstract: Abstract Introduction Tubulo-interstitial injury is a poor prognostic factor for lupus nephritis (LN). Here, we tested whether iguratimod could inhibit tubulo-interstitial injury in LN. Methods MRL/lpr mice, an animal model of lupus, were treated with… read more here.

Keywords: interstitial injury; mice; iguratimod; tubulo interstitial ... See more keywords