Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.7239
Abstract: Importance Trastuzumab deruxtecan (T-DXd) has shown efficacy in patients with breast cancer with ERBB2 immunohistochemistry (IHC) scores of 1+ or 2+ but not 0 as read in central pathology laboratories. The drug is currently being… read more here.
Keywords: ihc; erbb2; breast cancer; low erbb2 ... See more keywords
The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2017.10.013
Abstract: A significant portion of paragangliomas (PGL) and pheochromocytomas (PCC) occur in patients with hereditary PGL/PCC syndromes, including those with germline mutations in succinate dehydrogenase (SDHx) subunit genes. Recently, germline fumarate hydratase (FH) mutations have been… read more here.
Keywords: pgl pcc; pcc; sdhb immunohistochemistry; ihc ... See more keywords
Correlation between immunohistochemistry and RICTOR FISH amplification in small cell lung carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.08.018
Abstract: Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease, with no significant improvement in the field of targeted therapies. The RICTOR gene (rapamycin-insensitive companion of mTOR… read more here.
Keywords: rictor; ihc; rictor fish; phospho akt ... See more keywords
Decreased BIM expression in BCL2-negative follicular lymphoma: a potential mechanism for resistance to apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.09.016
Abstract: Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), leading to overexpression of the anti-apoptotic molecule BCL2; however, a subset of FLs lack BCL2 rearrangement and BCL2 expression by IHC. In this study we evaluated expression… read more here.
Keywords: bcl2 fls; ihc; follicular lymphoma; expression ... See more keywords
Pneumocystis jirovecii immunostain versus Gomori/Grocott methenamine silver stain of bronchoalveolar lavage in cell blocks: an institutional experience.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Cytopathology"
DOI: 10.1016/j.jasc.2017.06.207
Abstract: INTRODUCTION Current approaches to Pneumocystis jirovecii (PCJ) screening on bronchioalveolar lavage samples (BAL) include Gomori/Grocott methenamine silver stain (GMS), toluidine blue O stain, Wright-Giemsa stain, immunofluorescent antibody stain, and polymerase chain reaction. Another method available… read more here.
Keywords: pneumocystis jirovecii; gms; ihc; pcj ihc ... See more keywords
Combinational Analysis of FISH and Immunohistochemistry Reveals Rare Genomic Events in ALK Fusion Patterns in NSCLC that Responds to Crizotinib Treatment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2016.08.145
Abstract: Introduction: The purpose of this study was to explore the complicated rearrangement mechanisms underlying cases with atypical and negative anaplastic lymphoma receptor tyrosine kinase gene (ALK) fluorescence hybridization (FISH) and positive immunohistochemistry (IHC) results and… read more here.
Keywords: immunohistochemistry; alk; analysis; ihc ... See more keywords
A Phase II Study of Trastuzumab Emtansine in HER2‐Positive Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2017.10.032
Abstract: &NA; Trastuzumab emtansine (T‐DM1), an anti–erb‐b2 receptor tyrosine kinase 2 (HER2) antibody‐drug conjugate, has been shown to significantly improve survival in HER2‐positive breast cancer. We report a phase II trial of T‐DM1 monotherapy in relapsed… read more here.
Keywords: her2 positive; trastuzumab emtansine; ihc; cancer ... See more keywords
P1.09-04 Optimization of PD-L1 Testing Specimen Flow in the Greater Hamilton, Ontario Region
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.08.780
Abstract: their eligibility and predict responsiveness for immune-checkpoint inhibitors. Lung cancer is frequently diagnosed on cytology specimens. Although PD-L1 IHC assays are validated on formalin fixed paraffin embedded (FFPE) tissue, evidences are present in literature which… read more here.
Keywords: positivity; ihc; tumor cells; cytology ... See more keywords
Detection of ALK rearrangements in 4002 Russian patients: The utility of different diagnostic approaches.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2016.11.001
Abstract: BACKGROUND Clinical guidelines highly recommended the detection of potentially targetable genetic aberrations such as anaplastic lymphoma kinase (ALK) rearrangements in patients with non-small cell lung cancer (NSCLC). Few methods, such as the ALK break apart… read more here.
Keywords: detection; alk; ihc fish; russian patients ... See more keywords
Highly expressed EZH2 in combination with BAP1 and MTAP loss, as detected by immunohistochemistry, is useful for differentiating malignant pleural mesothelioma from reactive mesothelial hyperplasia.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.02.004
Abstract: OBJECTIVE Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Loss of BRCA-associated protein 1 (BAP1) protein expression as detected by immunohistochemistry (IHC) and homozygous deletion (HD) of the 9p21 locus as detected… read more here.
Keywords: mpm; bap1 mtap; combination bap1; bap1 ... See more keywords
A study of ALK-positive pulmonary squamous-cell carcinoma: From diagnostic methodologies to clinical efficacy.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.02.015
Abstract: BACKGROUND High concordance has been observed between Ventana D5F3 ALK immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) in lung adenocarcinoma (LADC). However, whether a similar conclusion can be applied to lung squamous-cell carcinoma (LSCC) has… read more here.
Keywords: alk; cell carcinoma; squamous cell; ihc ... See more keywords