Detection of ALK rearrangements in 4002 Russian patients: The utility of different diagnostic approaches.
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DOI: 10.1016/j.lungcan.2016.11.001
Abstract: BACKGROUND Clinical guidelines highly recommended the detection of potentially targetable genetic aberrations such as anaplastic lymphoma kinase (ALK) rearrangements in patients with non-small cell lung cancer (NSCLC). Few methods, such as the ALK break apart… read more here.
Keywords: detection; alk; ihc fish; russian patients ... See more keywords
RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance
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DOI: 10.1186/s12885-018-5070-6
Abstract: BackgroundRearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising targets in the therapy of advanced non-small cell lung cancer (NSCLC) and are predominantly detected by immunohistochemistry (IHC) and/or fluorescence in-situ hybridization (FISH). However,… read more here.
Keywords: rna based; fish positive; alk; ihc fish ... See more keywords