Investigation of Discrepant MMR IHC and MSI PCR Test Results for Gynecologic Cancers using Next Generation Sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Human pathology"
DOI: 10.1016/j.humpath.2021.10.004
Abstract: Gynecologic cancers are routinely screened for DNA mismatch repair (MMR) gene mutations using immunohistochemistry (IHC) and/or PCR for MSI (microsatellite instability) to enable selection of immune checkpoint inhibitor therapy and screen for Lynch syndrome. The… read more here.
Keywords: gynecologic cancers; ihc msi; msi; next generation ... See more keywords
Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls.
Sign Up to like & getrecommendations! Published in 2022 at "Personalized medicine"
DOI: 10.2217/pme-2021-0128
Abstract: We present the case of a patient with Lynch syndrome and metastatic colorectal carcinoma (mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a false negative result. However, the same mutation has accurately… read more here.
Keywords: ihc msi; case; microsatellite instability; lynch syndrome ... See more keywords