Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment
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DOI: 10.1016/j.bbrc.2020.04.003
Abstract: The human Ether-à-go-go Related Gene (hERG) encodes a potassium channel responsible for the cardiac rapid delayed rectifier K+ current, IKr, which regulates ventricular repolarization. Loss-of-function hERG mutations underpin the LQT2 form of congenital long QT… read more here.
Keywords: herg; iherg; channel; herg t634s ... See more keywords