Generation of an Ihh‐mKate2‐Dre knock‐in mouse line
Sign Up to like & getrecommendations! Published in 2022 at "genesis"
DOI: 10.1002/dvg.23488
Abstract: Indian hedgehog (Ihh), a member of the Hh family, plays important roles in vertebrate development and homeostasis. To improve our understanding of the function of Ihh‐expressing cells and their progeny as well, we generate an… read more here.
Keywords: dre; dre knock; ihh; mouse line ... See more keywords
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.08.020
Abstract: Abstract Immortalized human hepatocytes (IHH) could provide an unlimited supply of hepatocytes, but insufficient differentiation and phenotypic instability restrict their clinical application. This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A)… read more here.
Keywords: ihh; liver function; hnf4a; hepatic differentiation ... See more keywords
SLIT2 Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism
Sign Up to like & getrecommendations! Published in 2022 at "Hormone Research in Paediatrics"
DOI: 10.1159/000525769
Abstract: Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare reproductive disorder resulting from gonadotropin-releasing hormone (GnRH) deficiency. However, in only approximately half of patients with IHH is it possible to identify a likely molecular diagnosis. Mice… read more here.
Keywords: ihh; slit2; idiopathic hypogonadotropic; rare sequencing ... See more keywords
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease
Sign Up to like & getrecommendations! Published in 2022 at "Cartilage"
DOI: 10.1177/19476035221087706
Abstract: Objective To investigate the expression of Hedgehog (HH) signaling pathway proteins in knee articular cartilage from Kashin-Beck disease (KBD) and osteoarthritis (OA) patients. Methods Knee articular cartilage samples were collected from normal (N), OA, and… read more here.
Keywords: shh; ihh; pathway proteins; hedgehog ... See more keywords
Deletion of 2 amino acids in IHH in a Japanese family with brachydactyly type A1
Sign Up to like & getrecommendations! Published in 2021 at "BMC Medical Genomics"
DOI: 10.1186/s12920-021-01042-6
Abstract: Background Brachydactyly type A1 (BDA1) is an autosomal dominant disorder characterized by uniform shortening of the middle phalanges in all digits. It is associated with variants in the Indian Hedgehog ( IHH ) gene, which… read more here.
Keywords: japanese family; brachydactyly type; ihh; family ... See more keywords
Muscle Metaboreflex Control of Sympathetic Activity Is Preserved following Acute Intermittent Hypercapnic Hypoxia.
Sign Up to like & getrecommendations! Published in 2021 at "Medicine and science in sports and exercise"
DOI: 10.1249/mss.0000000000002716
Abstract: PURPOSE In normotensive patients with OSA, the muscle sympathetic nerve activity (MSNA) response to exercise is increased while metaboreflex control of MSNA is decreased. We tested the hypotheses that acute intermittent hypercapnic hypoxia (IHH) in… read more here.
Keywords: ihh; metaboreflex control; msna; activity ... See more keywords
Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH).
Sign Up to like & getrecommendations! Published in 2018 at "European journal of endocrinology"
DOI: 10.1530/eje-17-0065
Abstract: OBJECTIVE Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their… read more here.
Keywords: ihh; isolated hypogonadotropic; cohort; hypogonadism ihh ... See more keywords
Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.01036
Abstract: Loss-of-function mutations in GLI3 and IHH cause craniosynostosis and reduced osteogenesis, respectively. In this study, we show that Ihh ligand, the receptor Ptch1 and Gli transcription factors are differentially expressed in embryonic mouse calvaria osteogenic… read more here.
Keywords: ihh; runx2; ligand; gli3 ... See more keywords
Discrete Hedgehog Factor Expression and Action in the Developing Phallus
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21041237
Abstract: Hypospadias is a failure of urethral closure within the penis occurring in 1 in 125 boys at birth and is increasing in frequency. While paracrine hedgehog signalling is implicated in the process of urethral closure,… read more here.
Keywords: ihh; ontology; closure; hedgehog ... See more keywords
Knockdown of Indian hedgehog protein induces an inhibition of cell growth and differentiation in osteoblast MC3T3-E1 cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7669
Abstract: Indian hedgehog protein (Ihh) is evolutionarily conserved and serves important roles in controlling the differentiation of progenitor cells into osteoblasts. Ihh null mutant mice exhibit a failure of osteoblast development in endochondral bone. Although studies… read more here.
Keywords: ihh; cell; differentiation; indian hedgehog ... See more keywords
MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11296
Abstract: Indian hedgehog signaling molecule (Ihh) is known to play critical roles in chondrogenesis and cartilage development. However, it remains largely unknown how Ihh is regulated during the process. Previous studies suggest that Ihh plays an… read more here.
Keywords: ihh; chondrocyte differentiation; expression; ihh expression ... See more keywords